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Associate Director, Plasmid Process Development Manufacturing

Company: Homology Medicines
Location: Bedford
Posted on: December 5, 2019

Job Description:

Employer Homology Medicines Location 01730, Bedford Posted Nov 07, 2019 Discipline Engineering, Chemical Engineer, Process Engineer, Manufacturing & Production, Process, Science/R & D, Bioengineering Required Education Doctorate/PHD/MD Position Type Full time You need to sign in or create an account to save Associate Director, Plasmid Process Development & Manufacturing Location: Bedford, MA Homology Medicines seeks an outstanding Associate Director in the Upstream Process Development team to oversee the development of plasmid DNA production and purification manufacturing platforms. The individual in this role will be a highly-skilled, talented and motivated scientist who will focus on leading a new team to aid in the development, characterization, and scale up of methods for producing and purifying plasmid DNA. We seek candidates with proven ability to work independently in the lab and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients. Essential Functions and Duties Lead and manage a team in the development of upstream fermentation and downstream purification for DNA plasmids Plan and execute studies related to bacterial fermentation and yield improvements Develop and execute process steps related to cell lysis and clarification Coordinate experiments to develop multiple chromatography-based purification for product capture and enrichment Evaluate raw materials and equipment ensuring scalability and compatibility with GMP operations and tech transfer Interact with external partners to review data and batch records Develop SOP's, batch records, and provide technical support and training to others Skills and Experience BS (12+), MS (10+), or PhD (6+) years industry experience. Degree experience in microbiology, biochemistry, or molecular biology. Previous production or purification of biologic products in bacterial culture systems Direct management experience of research or development teams is required Industry experience in the manufacturing of DNA products in fermentation bioreactors strongly preferred Molecular techniques including DNA sequencing, restriction digest analysis, gel electrophoresis, and ELISAs Proven leadership experience and management skills with ability to work in a fast-paced, highly collaborative environment Strong verbal and written communication skills Interested candidates my forward CV and Cover Letter to ***************************** Or apply on line: ***************************************************************************************************** Homology Medicines, Inc. (HMI) has built foundational intellectual property on gene editing and gene therapy vectors derived from naturally occurring human adeno-associated viruses (AAVs). The Company's technology is precise, on-target and highly efficient for in vivo editing of genetic mutations. This transformative platform technology, combined with an elite leadership team of biopharmaceutical industry veterans, create a significant opportunity for HMI to rapidly advance a diverse pipeline of new medicines that address and potentially cure the underlying cause of genetic diseases . More searches like this Engineering jobs in Bedford Chemical Engineer jobs in Bedford Process Engineer jobs in Bedford Manufacturing & Production jobs in Bedford Process jobs in Bedford

Keywords: Homology Medicines, Boston , Associate Director, Plasmid Process Development Manufacturing, Executive , Bedford, Massachusetts

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