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Sr. Director, Head of Veterinary Pathology

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

Vertex is seeking a senior level Veterinary Pathologist to lead our Veterinary Pathology team. Veterinary Pathology is a critical function residing within Preclinical Safety Assessment and Bioanalysis (PSA&BA) responsible for conduct, evaluation, and interpretation of pathology endpoints related to animal model development, in vivo pharmacology and nonclinical biomarker development, and safety assessment evaluations of Vertex new chemical entities. The Head of Veterinary Pathology will report directly to the Global Head of PSA&BA and will be a contributing member of their Leadership Team. Prospective candidates should have a passion for learning, strong technical, communication, and organizational skills as well as a sense of creativity. Preclinical Safety Assessment (PSA) is a global function responsible for the design and conduct of comprehensive nonclinical safety programs for the evaluation of Vertex therapies at all stages of discovery and development. Vertex Pharmaceuticals uses cutting edge science and technology to perform robust assessments of novel therapies for the treatment of the most serious diseases with unmet medical need. Our culture enables individual empowerment where We Wins, Fearless Pursuit of Excellence, Innovation, and Commitment to patients are more than just corporate values; they are part of our everyday lives. PSA pathologists have significant roles in the drug development process beginning in early discovery and continuing through the entire drug development value chain resulting in successful registration and marketing approval.

Key Responsibilities:

* Leading a growing team of innovative veterinary toxicologic pathologists and histopathology core laboratory staff responsible for expert scientific leadership in discovery, translational research, and regulatory nonclinical safety profiling activities as key partners on cross-functional teams within Vertex and an extensive network of consultants and contract research organizations * Anatomic pathology evaluation of investigative pathology and regulatory toxicity studies from lead identification/optimization through registration and post-marketing including peer review of outsourced non-GLP and GLP-compliant toxicity studies * Strategic and scientific oversight of the design, conduct and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies including the use of cutting-edge molecular diagnostic and digital imaging technologies conducted by a high-functioning multidisciplinary team of preclinical safety scientists * Participation in regulatory submission document preparation, poster presentations and scientific publications, including addressing queries from global health authorities * Contributing member of the PSA & BA Leadership Team

The position includes opportunities for potential additional roles including:

* Preclinical safety representative on discovery and/or development project teams * Nonclinical safety evaluation of in-licensing opportunities supporting business development

Minimal Requirements :

* DVM or equivalent and ACVP/ECVP board certification in veterinary anatomic pathology * PhD in a relevant scientific discipline is strongly preferred * 15+ years of work experience in Discovery and/or Toxicologic Pathology in the pharmaceutical/biotechnology sector including the conduct of GLP peer reviews * Demonstrated excellence in oral and written communications, critical thinking and issue resolution skills, scientific collaboration, guidance, and mentoring of non-DVM scientists and laboratory associates * Extensive practical expertise in the use of imaging technologies and molecular diagnostic pathology techniques to understand the pathologic basis of disease and support drug discovery and development is highly desirable

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Keywords: Vertex Pharmaceuticals Inc (US), Boston , Sr. Director, Head of Veterinary Pathology, Executive , Boston, Massachusetts

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