Associate Director DMPK Project Lead

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

We are seeking an exceptional scientist, leader and cross-functional collaborator to join our Drug Metabolism and Pharmacokinetics (DMPK) team in Boston. The individual serve as the DMPK Project Lead on cross-functional teams and help advance discovery and development of transformational therapies for serious unmet medical needs.

Key Responsibilities:

* Develop and execute scientific strategies to address ADME challenges on discovery and development programs. * Build and maintain strong collaborative partnerships with Medicinal Chemistry, Biology, Preclinical Safety, Clinical Pharmacology, CMC and other R&D disciplines to advance Vertex programs through discovery and development. * Represent DMPK function on drug discovery and development teams and at Vertex R & D governance bodies. * Implement and utilize innovative DMPK technologies and approaches to enhance scientific impact and/or efficiencies. * Provides scientific and managerial leadership to the team in prioritizing and executing on key deliverables and project needs. * Ensure completion of necessary DMPK regulatory documentation and reports to support drug development including Investigator Brochures, INDs (or equivalent), and marketing applications. * Develop internal and external sourcing strategies and liaise across sites to best meet portfolio needs. * Participate in assessment of business development opportunities.

Minimum Requirements:

* PhD or equivalent, with >8 years of experience working in a multifunctional DMPK group in a pharmaceutical company * Successful track record and experience in a DMPK Lead role on multiple R & D teams across more than one therapeutic area. Ability to influence and lead functional and cross-functional colleagues * Broad understanding of the drug discovery and development process and cross-functional dependencies * Deep scientific and strategic expertise various components of predictive and translational DMPK science such as pharmacokinetics, in vitro and in vivo ADME, mass spectrometry and bioanalysis, pharmacokinetic data analysis and interpretation, biotransformation / disposition pathways, drug interaction risk assessment and human pharmacokinetics and dose predictions. Additional skills and familiarity in areas such as transporter science, enzymology, chemistry, and PK/PD and PBPK modeling will be a strong plus. * Ability to stay abreast and critically evaluate scientific literature and new technology as it relates to the discovery and development of new medicines * Excellent verbal, written and interpersonal communication skills, and ability to develop and grow strong cross-site/function collaborations

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Keywords: Vertex Pharmaceuticals Inc (US), Boston , Associate Director DMPK Project Lead, Executive , Boston, Massachusetts