Director, Immunotherapy/ Immuno-Oncology, In Vitro Pharmacology
Company: Takeda Pharmaceutical
Location: Boston
Posted on: September 30, 2024
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAbout the role:At Takeda, we are a
forward-looking, world-class R&D organization that unlocks
innovation and delivers transformative therapies to patients. By
focusing R&D efforts on four therapeutic areas and other
targeted investments, we push the boundaries of what is possible in
order to bring life-changing therapies to patients worldwide.Join
Takeda as a Director where you will evaluate the biological
activity of the potential therapeutics candidates generated in
global biologics and select the best candidates for further
preclinical and clinical development. You will also lead a team
responsible for designing and implementing vitro pharmacological
assays, utilizing state-of-the-art technologies and methodologies,
leading the discovery of novel biologics, and contributing to the
strategic direction of our Immunotherapy and Immuno-oncology
research programs. As part of the In Vitro Pharmacology team, you
will report to the Head of the team and work with the Global
Biologics organization.How you will contribute:
- Strategic Leadership: Provide strategic direction and
leadership for the Immunotherapy and Immuno-oncology in vitro
pharmacology team, ensuring alignment with company goals and
objectives. Develop and implement innovative strategies to support
the discovery and development of novel therapies.
- Functional Leadership: Lead the design, development,
optimization and execution of high-quality in vitro pharmacology
assays to evaluate the activity, mechanism of action, and efficacy
of Immunotherapy and Immuno-oncology therapeutics. Utilize
cutting-edge technologies and methodologies to assess immune cell
function, immune checkpoint pathways, and tumor-immune
interactions. Develop and implement strategies to enhance the in
vitro pharmacology capabilities and throughput. Stay abreast of the
latest scientific advancements and industry trends.
- Program Leadership: Lead the Immunotherapy and Immuno-oncology
biologics discovery programs with cross-functional teams, driving
the programs from lead ID to preclinical development.
- Candidates Screening and Profiling: Oversee the screening and
profiling of biologic drug candidates in relevant in vitro models
including immune cell-based assays, co-culture systems, and 3D
organoid models. Evaluate candidate efficacy, potency and
selectivity, to support lead optimization and candidate
selection.
- Mechanism of Action Studies: Investigate the molecular
mechanisms underlying the activity of therapeutic candidates using
in vitro pharmacology approaches. Characterize interactions with
immune targets, signaling pathways, and immune cell subsets to
elucidate therapeutic mechanisms and inform drug development
strategies.
- Cross-Functional Collaboration: Collaborate closely with
interdisciplinary discovery teams in a matrix format, including
biologics engineering, biologics production, analytics,
translational scientists, and preclinical development teams to
advance discovery programs. Communicate results effectively and
contribute to project team meetings, scientific discussions, and
project planning activities.
- Mentoring: Mentor and develop junior scientists, fostering a
culture of innovation, collaboration, and scientific
excellence.Minimum Requirements/Qualifications:
- PhD degree in immunology, cancer biology, or a related
scientific discipline with 10+ years experience , or MS with 16+
years experience, or BS with 18+ years experience.
- Minimum of 10 years of experience in
Immunotherapy/immuno-oncology research, with a focus on immune cell
biology, immune checkpoints, and tumor-immune interactions.
- Minimum of 7 years of management experience.
- Expertise in drug discovery and development processes,
including hit identification, lead optimization, candidate
selection, and preclinical development.
- Proven track record of leading successful in vitro pharmacology
efforts in the field of immunotherapy/immuno-oncology , including
assay development and validation, candidates screening, and
mechanism of action studies.
- Strong technical proficiency in a wide range of in vitro
pharmacology techniques and assay formats.
- Excellent leadership, communication, and interpersonal skills,
with the ability to lead a team and projects and collaborate
effectively across disciplines, demonstrate enterprise leadership
with an ability to influence without authority.
- Knowledge of regulatory requirements and guidelines for drug
discovery and developmentMore about us:At Takeda, we are
transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work.Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the
world.#LI-SGM#LI-OnsiteTakeda Compensation and Benefits SummaryWe
understand compensation is an important factor as you consider the
next step in your career. We are committed to equitable pay for all
employees, and we strive to be more transparent with our pay
practices. -For Location:Boston, MAU.S. Base Salary
Range:$169,400.00 - $266,200.00The estimated salary range reflects
an anticipated range for this position. The actual base salary
offered may depend on a variety of factors, including the
qualifications of the individual applicant for the position, years
of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.---The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. -U.S. based employees may be
eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Boston , Director, Immunotherapy/ Immuno-Oncology, In Vitro Pharmacology, Executive , Boston, Massachusetts
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