Associate Computational Biologist I - Engreitz Lab
Company: Broad Institute
Posted on: January 17, 2020
MAPPING THE REGULATORY WIRING OF THE GENOME TO DISCOVER GENETIC
RISK FACTORS FOR HEART DISEASE
Contact: Jesse Engreitz (email@example.com)
* We are hiring for several positions in the Engreitz Laboratory to
map the regulatory wiring of the human genome to discover genetic
mechanisms of heart diseases.
This is a limited time position and will end on April 30, 2020. *
The Engreitz Lab is currently located at the Broad Institute, and
will move to the Stanford University Department of Genetics and
Children s Heart Center in May 2020. The ideal candidate will join
us at the Broad Institute in January 2020 and be willing to move
with the lab to Stanford University.
* DNA regulatory elements in the human genome harbor thousands of
genetic risk variants for common and rare diseases and could reveal
targets for therapeutics that aim to precisely tune cellular
functions if only we could map the complex regulatory wiring that
connects 2 million regulatory elements with 21,000 genes in
thousands of cell types in the human body. We have recently
developed new approaches that could enable mapping this regulatory
wiring at massive scale. We invent new tools combining experimental
and computational genomics, biochemistry, molecular biology, and
human genetics to assemble regulatory maps of the human genome and
uncover biological mechanisms of heart disease.
* We are looking for creative and passionate people at any stage in
their careers, including: lab manager, senior research scientists,
research associates, postdoctoral fellows, and graduate students.
Ideal candidates will train to lead and design experimental and/or
computational projects that push the boundaries of human genetics
and reveal the functions of genetic variants associated with heart
* Specific projects include: to develop CRISPR-based tools to map
the functions of thousands of noncoding variants and enhancers;
chart enhancer-promoter regulation in every cell type and state in
the developing heart using single-cell CRISPR and epigenomic tools;
understand enhancer-promoter biochemical specificity by synthetic
DNA engineering of millions of enhancer-promoter combinations; and
develop novel computational models to understand genetic regulation
of heart disease by noncoding variants. For more information and
recent work, see www.engreitzlab.org
* The Engreitz Laboratory is a dynamic, interdisciplinary workplace
that will provide unique access to cutting edge technologies and
scientific thought, with the potential for widespread recognition
of scientific contributions. We value a diversity of values,
backgrounds, and approaches to solving problems.
* Collaborate with experimentalists and computational biologists to
develop and apply functional genomics techniques
* Design and implement generalizable algorithms and tools for
analysis of biological data, including high-throughput functional
* Evaluate and recommend new emerging technologies, approaches, and
* Create scientifically rigorous visualizations, communications,
and presentations of results
* Contribute to generation of protocols, publications, and
* Maintain and organize computational infrastructure and
* Suggested: B.S. in computational biology, computer science,
physics, statistics, math, molecular biology, or related field.
Talented applicants of all levels are encouraged to apply.
* Demonstrated expertise in statistical methods in data analysis,
preferably with applications to high-throughput sequencing or other
* Enthusiasm for using computational approaches to learn
fundamental mechanisms of gene regulation and understand human
* Fluency in Unix, standard bioinformatics tools (Python, R, or
equivalent), and a programming language (C/C++, Java)
* Excellent communication, organization, and time management
* Creative, organized, motivated, team player
THIS POSITION IS FOR A FIXED TERM ENDING ON APRIL 30TH, 2020. AFTER
THAT DATE THE PI (DR. ENGREITZ) WILL BE MOVING HIS LAB AND FUNDING
FROM THE BROAD INSTITUTE TO STANFORD UNIVERSITY IN PALO ALTO, CA.
THIS BROAD FIXED TERM POSITION WILL END ON APRIL 30TH AND IT IS
EXPECTED AS A CONDITION OF EMPLOYMENT AT THE BROAD, THAT THE
CANDIDATE IS COMMITTED TO APPLYING FOR EMPLOYMENT WITH STANFORD AND
WILLING TO RELOCATE TO THE NEW LAB IF OFFERED THE POSITION AFTER
THE END OF EMPLOYMENT WITH THE BROAD INSTITUTE.
THE BROAD INSTITUTE WILL NOT OFFER VISA SPONSORSHIP FOR THIS
ALL QUALIFIED APPLICANTS WILL RECEIVE CONSIDERATION FOR EMPLOYMENT
WITHOUT REGARD TO RACE, COLOR, RELIGION, SEX, SEXUAL ORIENTATION,
GENDER IDENTITY, NATIONAL ORIGIN, DISABILITY OR PROTECTED VETERAN
STATUS.EEO is The Law - For more information, please visit the
Equal Opportunity Employer Minorities/Women/Protected
Veterans/Disabled - For more information, please visit the
Keywords: Broad Institute, Boston , Associate Computational Biologist I - Engreitz Lab, Healthcare , Cambridge, Massachusetts
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