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Associate Computational Biologist I - Engreitz Lab

Company: Broad Institute
Location: Cambridge
Posted on: January 17, 2020

Job Description:

JOB DESCRIPTION

MAPPING THE REGULATORY WIRING OF THE GENOME TO DISCOVER GENETIC RISK FACTORS FOR HEART DISEASE

Contact: Jesse Engreitz (engreitz@broadinstitute.org)

JOB DESCRIPTION

* We are hiring for several positions in the Engreitz Laboratory to map the regulatory wiring of the human genome to discover genetic mechanisms of heart diseases.

*

This is a limited time position and will end on April 30, 2020. * The Engreitz Lab is currently located at the Broad Institute, and will move to the Stanford University Department of Genetics and Children s Heart Center in May 2020. The ideal candidate will join us at the Broad Institute in January 2020 and be willing to move with the lab to Stanford University.

* DNA regulatory elements in the human genome harbor thousands of genetic risk variants for common and rare diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale. We invent new tools combining experimental and computational genomics, biochemistry, molecular biology, and human genetics to assemble regulatory maps of the human genome and uncover biological mechanisms of heart disease.

* We are looking for creative and passionate people at any stage in their careers, including: lab manager, senior research scientists, research associates, postdoctoral fellows, and graduate students. Ideal candidates will train to lead and design experimental and/or computational projects that push the boundaries of human genetics and reveal the functions of genetic variants associated with heart disease.

* Specific projects include: to develop CRISPR-based tools to map the functions of thousands of noncoding variants and enhancers; chart enhancer-promoter regulation in every cell type and state in the developing heart using single-cell CRISPR and epigenomic tools; understand enhancer-promoter biochemical specificity by synthetic DNA engineering of millions of enhancer-promoter combinations; and develop novel computational models to understand genetic regulation of heart disease by noncoding variants. For more information and recent work, see www.engreitzlab.org

* The Engreitz Laboratory is a dynamic, interdisciplinary workplace that will provide unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.

CHARACTERISTIC DUTIES

* Collaborate with experimentalists and computational biologists to develop and apply functional genomics techniques

* Design and implement generalizable algorithms and tools for analysis of biological data, including high-throughput functional genomics assays

* Evaluate and recommend new emerging technologies, approaches, and problems

* Create scientifically rigorous visualizations, communications, and presentations of results

* Contribute to generation of protocols, publications, and intellectual property

* Maintain and organize computational infrastructure and resources

QUALIFICATIONS

* Suggested: B.S. in computational biology, computer science, physics, statistics, math, molecular biology, or related field. Talented applicants of all levels are encouraged to apply.

* Demonstrated expertise in statistical methods in data analysis, preferably with applications to high-throughput sequencing or other biological assays

* Enthusiasm for using computational approaches to learn fundamental mechanisms of gene regulation and understand human disease

* Fluency in Unix, standard bioinformatics tools (Python, R, or equivalent), and a programming language (C/C++, Java)

* Excellent communication, organization, and time management skills

* Creative, organized, motivated, team player

THIS POSITION IS FOR A FIXED TERM ENDING ON APRIL 30TH, 2020. AFTER THAT DATE THE PI (DR. ENGREITZ) WILL BE MOVING HIS LAB AND FUNDING FROM THE BROAD INSTITUTE TO STANFORD UNIVERSITY IN PALO ALTO, CA. THIS BROAD FIXED TERM POSITION WILL END ON APRIL 30TH AND IT IS EXPECTED AS A CONDITION OF EMPLOYMENT AT THE BROAD, THAT THE CANDIDATE IS COMMITTED TO APPLYING FOR EMPLOYMENT WITH STANFORD AND WILLING TO RELOCATE TO THE NEW LAB IF OFFERED THE POSITION AFTER THE END OF EMPLOYMENT WITH THE BROAD INSTITUTE.



THE BROAD INSTITUTE WILL NOT OFFER VISA SPONSORSHIP FOR THIS OPPORTUNITY.

ALL QUALIFIED APPLICANTS WILL RECEIVE CONSIDERATION FOR EMPLOYMENT WITHOUT REGARD TO RACE, COLOR, RELIGION, SEX, SEXUAL ORIENTATION, GENDER IDENTITY, NATIONAL ORIGIN, DISABILITY OR PROTECTED VETERAN STATUS.EEO is The Law - For more information, please visit the following link:

https://www.candidatecare.com/srccar/2016eeoposter.dbprop?x=y&oemID=RTI_1131007&_ext=pdf

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled - For more information, please visit the following link:

https://www.candidatecare.com/srccar/PolicyPayTransparency2016.dbprop?x=y&oemID=RTI_1131007&_ext=pdf

Keywords: Broad Institute, Boston , Associate Computational Biologist I - Engreitz Lab, Healthcare , Cambridge, Massachusetts

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