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Senior Anatomic Pathologist

Company: Vertex Pharmaceuticals
Location: Boston
Posted on: September 17, 2020

Job Description:

Preclinical Safety Assessment (PSA) is a global function responsible for the design and conduct of comprehensive nonclinical safety programs for the evaluation of Vertex therapies at all stages of discovery and development. Vertex Pharmaceuticals uses cutting edge science and technology to perform robust assessments of novel therapies for the treatment of the most serious diseases with unmet medical need. Our culture enables individual empowerment where We Wins, Fearless Pursuit of Excellence, and Innovation are more than just corporate values; they are part of our everyday lives. PSA pathologists have significant roles in the drug development process beginning in early discovery and continuing through the entire drug development value chain resulting in successful registration and marketing approval.

Key Responsibilities:

* Anatomic pathology evaluation of nonGLP and GLP Toxicity studies from lead identification/optimization stage through registration and post-marketing in collaboration with other veterinary anatomic and clinical pathologists * Peer review of nonGLP and GLP toxicology studies including carcinogenicity studies * Scientific leadership in the design, conduct and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies * Anatomic pathology evaluation of Translational Biology in vivo efficacy studies and animal model development including the use of molecular diagnostic and digital imaging technologies * Interpretation and communication of findings to cross-functional project teams and senior management * Collaboration with PSA, Discovery and Biomarker scientists to identify translational safety biomarkers for possible use in clinical studies * Participation in regulatory submission document preparation, poster presentations and scientific publications, including addressing queries from global health authorities * The position includes opportunities for potential additional roles including: Preclinical safety representative on discovery and/or development project teams * Nonclinical safety evaluation of in-licensing opportunities supporting business development

Minimal Requirements :

* DVM or equivalent and ACVP/ECVP board certification in veterinary anatomic pathology * PhD in a relevant scientific discipline is strongly preferred * 10 years of work experience in Discovery and/or Toxicologic pathology in the pharmaceutical/biotechnology sector including the conduct of GLP peer reviews * Work experience as a project team representative in the pharmaceutical/biotechnology sector is desirable * Demonstrated excellence in oral and written communication skills, including authorship of regulated pathology reports * Work experience in issue resolution, scientific collaboration, guidance and mentoring of junior pathologists

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Keywords: Vertex Pharmaceuticals, Boston , Senior Anatomic Pathologist, Healthcare , Boston, Massachusetts

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