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Technical Research Asstistant II / 40 HR/ DAY / Department of Medicine Channing

Company: Brigham and Women's Hospital
Location: Boston
Posted on: April 11, 2021

Job Description:

GENERAL SUMMARY/ OVERVIEW STATEMENT: Summarize the nature and level of work performed. The Channing Division of Network Medicine is a research division within the Department of Medicine at Brigham and Women's Hospital. The Channing mission is: To use an integrated, network-based, systems biology-driven approach to define the etiology of complex diseases; to reclassify complex diseases based on systems pathobiological mechanisms; and to develop new treatments and preventive strategies based on these new disease classifications using systems pharmacology approaches. To these aims, one of the three units of the Channing, the Chronic Disease Epidemiology unit, includes several of the largest, most intensively studied, longitudinal cohorts in the world, including the Nurses' Health Study, the Health Professionals Follow-up Study, Growing Up Today Study, and the Physician's Health Study. Epidemiology of a broad range of complex chronic diseases is studied in these cohorts, using a variety of traditional and novel approaches, including genomics, metabolomics, and molecular pathoepidemiology. Biospecimen from these and other well-known research studies are the custody of the BWH/Harvard Cohorts Biorepository. As one of the largest longitudinal biorepositories in the country, the Cohorts Biorepository manages the safe storage of over 3-million research biospecimen and distributes an average of 50,000 specimens annually for research. We are currently expanding our capabilities to manage specimen collections from research subjects. We are currently recruiting for an intermediate laboratory position to perform laboratory work and office duties associated with the cohorts Biorepository under supervision of the Senior Lab Manager. Routine duties involve preparation of specimens, drawn from two banks, for distribution to assay laboratories for biochemical analyses. This includes generating all necessary computer files; creation of shipping lists and labels using appropriate software programs; labeling of tubes and shipping boxes; removal of blood from freezers; thawing and aliquoting of samples to be sent to collaborating laboratories; creation of sub-aliquots in appropriate volumes; careful check of contents of boxes against shipping lists; updating computer and hardcopy files of work accomplished; and arranging shipment of samples to collaborating laboratories via Federal Express. Additional duties include: assistance with ongoing and new collections-processing, storing and organizing specimens in liquid nitrogen vapor freezers for future analysis; consolidating existing freezers to optimize space; monitoring the liquid nitrogen storage facility and responding to freezer emergency and oxygen sensor alarms. PRINCIPAL DUTIES AND RESPONSIBILITIES: Indicate key areas of responsibility, major job duties, special projects and key objectives for this position. These items should be evaluated throughout the year and included in the written annual evaluation. This position does NOT involve Patient Care. 1. Collections: This candidate must be fluent in LIMS. The primary responsibility for this position is in collections. The TRAII is expected to have a vast knowledge and expertise in receipt and processing of incoming biospecimen: Responsible on a day-to-day basis, under the Senior Laboratory Manager, for receiving, opening and checking incoming specimen collection kits for completeness, logging received kits and specimens into a LIMS system and logbooks, processing biospecimen according to standardized SOPs, and storing samples in liquid nitrogen freezers. Assisting in the design and development of collections from kit and questionnaire design to writing SOP for fellow technicians and instruction manuals for participants. Assist in graphic design for print material associated with the collection. Addressing issues as they arise when kits are received. Ability to interact with the participants to answer and record their questions. Perform data entry tasks and when issues are seen, enter a ticket into Redmine to request a repair to the LIMS and work with programmers to ensure all details surround the issue are clear. Design and perform QC tests of the location of samples in the freezer to confirm proper data entry 2. Production and Distribution P/D: The candidate will primarily assist with pulling and aliquoting samples from P/D and double checking the work from completeness only because the level of the work for this candidate with be primarily in Collections. However, when needed during times of great need. The candidate is well versed in P/D and may be asked to prepare specimens for distribution. This means the incumbent is required to participate in the preparation of blood samples, drawn from two banks of specimens for biochemical analyses. This includes creation of shipping lists and labels using appropriate software programs (such as the LIMS and GENERATE), labeling of tubes and shipping boxes, removal of blood from freezers (involves lifting 26 lb. racks), thawing and aliquoting of samples to be sent to collaborating laboratories as well as creation of sub-aliquots in appropriate volumes, determination of which Quality Control (QCs) samples to use and addition of the QCs, careful check of contents of boxes against shipping lists, updating of computer and hardcopy files of work accomplished, and shipment of samples to collaborating laboratories via Federal Express and/or Quik International. 3. Data Recordation: Incumbent will be or expected to become a fluent LIMS user and assist the project manager regularly in discussions about process improvement and workflow needs. 4. Biorepository Monitoring: Incumbent will be highly involved in monitoring: freezer health, liquid nitrogen levels, LN2 Piping System pressure, and external bulk deliveries. This includes, upkeep of freezer and repair logs; measuring liquid Nitrogen levels; and ordering, moving and replacing heavy liquid nitrogen Dewars or freezers. Also assists in monitoring 8 mechanical freezers for thermal accuracy and weekly confirmation of properly functioning alarm systems. Responds promptly and efficiently to any freezer alarm situation and contacts the Laboratory Manager, communicates with facilities maintenance and repair personnel when warranted. Every two months, carry the On-Call pager for a week, and respond to all night and weekend alarm calls. 5. Consolidation Project: Inventory and Quality Control: When required, incumbent will assist in the consolidation of specimen collections within Liquid Nitrogen (LN2) freezers to optimize sample storage space, Re-label existing vials with 2-D Barcode labels to enhance ease of tracking vials, Add sentinel vials to each new and then carefully move relabeled vials from existing box into these new boxes, Update inventory records and, consolidate boxes from one rack to another and move racks, as needed, from freezer to freezer. Design and perform QC tests of the Consolidated freezers to confirm proper data entry. 6. Communications: Incumbent will be required to serve as a liaison of the organization in working with partner laboratories, third party companies, and other logistical and shipping entities inside and outside of BWH when asked. 7. General: As needed, incumbent will be required to contribute to other general activities such as writing Standard Operating Procedures (SOPs), answering participant questions regarding collection and shipping via email or phone, general lab maintenance, conduct supply inventory updates and ordering of needed supplies via Peoplesoft, as well as, work on special projects: such as the toenail inventory update in LIMS. * Bachelors degree in life sciences, required;* One year of experience in a bio-repository, handling human biological specimen, strongly preferred;* Experience with Questionnaire and Instruction writing and design a plus;* Experience with LIMS to process kits and record all data associated with incoming collection material. LIMS design experience desired.* Demonstrated careful laboratory techniques, with strict attention to detail, and accuracy with study data and numeric identification numbers is essential;* Excellent organizational, interpersonal, and communication skills required;* High degree of customer service and business acumen;* Expertise, to be at ease when answering questions.* Ability to lift 26-pound freezer racks- see "PHYSICAL/ENVIRONMENTAL REQUIREMENTS OF THE JOB" (Below);* Proficiency with Word, Excel, and Powerpoint is essential with experience in UNIX, Databases, and/or LIMS a plus PHYSICAL REQUIREMENTS OF THE JOB: Work Environment: Activity Amount of Time Spent None 1 - 25% 25 - 50% 50 - 75% Over 75% Outdoor weather conditions X to deliver samples to local labs Extreme cold (non-weather) X Work in high place(s) X Work in confined space(s) X Risk of electrical shock X Risk of radiation exposure X Exposure to blood borne pathogens X Flammable/explosive gases X Toxic / caustic chemicals X Dust or other irritants X Grease or oils X Hazardous specimens X Exposure to lab animals X Infectious / contagious disease X Cleaning agents/chemicals X Hot equipment X Noisy equipment X Humid or wet conditions (non -weather) X Other LN2: LIQUID NITROGEN X Lifting/Carry Requirements of this job No Lifting required No Carrying required Number of pounds Amount of Time 1 - 25% 25 - 50% 50 - 75% Over 75% Lift Carry Lift Carry Lift Carry Lift Carry Up to 10 pounds X X Up to 25 pounds X X Up to 50 pounds Up to 100 pounds Over 100 pounds Push/Pull Requirements of this job: No Pushing required No Pulling required Number of pounds Amount of Time 1 - 25% 25 - 50% 50 - 75% Over 75% Push Pull Push Pull Push Pull Push Pull Up to 10 pounds X X Up to 25 pounds X X Up to 50 pounds X X Up to 100 pounds X X Over 100 pounds X X Physical Activity requirements of this job: Activity Amount of Time Spent None 1 - 25% 25 - 50% 50 - 75% Over 75% Stand X Walk X Sit X Use of hands requiring fine motor skills and sense of touch X Move / rotate / bend wrist(s) X Type / use keyboard or other data entry device X Reach with hands & arms X Climb stairs X Climb ladder or other equipment X Drive / operate motor vehicle X Balance X Stoop, kneel, crouch, bend, crawl X Speak X Hear X Taste X Smell X Other Vision Requirements of this job: Vision Requirement Required Not Required Close vision X Distance vision X Color vision X Peripheral vision X Depth perception X Ability to adjust focus X Other Safety equipment used while performing this job: Safety eye glasses X Gowns Filter lens (welding/soldering) Scrubs Face shields X Boots Ear plugs or Mufflers Hard hat Surgical mask / dust mask X Coveralls Self-contained breathing apparatus (SCBA) Gloves X Other X LAB COAT, and Ear plugs while sonicating Level of noise typical in this work environment: Very quiet Quiet Moderate X Loud Very loud

Keywords: Brigham and Women's Hospital, Boston , Technical Research Asstistant II / 40 HR/ DAY / Department of Medicine Channing, Human Resources , Boston, Massachusetts

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