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Bioinformatician

Company: Beth Israel Deaconess Medical Center
Location: Boston
Posted on: December 5, 2019

Job Description:

Education - Doctoral Degree - Master's Degree Skills - Data Collection - Microsoft Word - Microsoft Access - Excel - Regression Analysis Department Description: Senior Bioinformatician, BIDMC Endocrinology and BNORC FGB Core Job Summary: To carry out and consult on NGS data analysis for a variety of projects in support of the Rosen/Tsai Laboratories of BIDMC and the Functional Genomics and Bioinformatics Core of the Boston Nutrition Obesity Research Center (BNORC). Job Location: Boston, MA Req ID: 32395BR Job Summary: To carry out and consult on NGS data analysis for a variety of projects in support of the Rosen/Tsai Laboratories of BIDMC and the Functional Genomics and Bioinformatics Core of the Boston Nutrition Obesity Research Center (BNORC). Responsibilities: 1. Design, implement, and NGS pipelines for ChIP-, RNA-, ATAC-, single cell RNA-seq datasets and genotyping arrays for members of the Endocrinology Division and BNORC clients. Within the division, most work is done with Evan Rosen (primary), Bradford Lowell, and Linus Tsai, along with BNORC clients from BU, Tufts, MGH, and Joslin. 2. Research and carry out state-of-the-art methods for data integration and modeling. 3. Manage datasets generated by collaborators. 4. Generate publication-ready figures for select projects. 5. Communicate all aspects of the analyses to experimental biologists. 6. Manage and provide mentorship for junior bioinformaticians. Essential Responsibilities: Assists in the design, development and maintenance of data collection instruments, databases and procedure manuals. Designs, implements, and performs data management and quality control procedures as necessary for routine and special projects. Writes computer programs to combine data from separate computer files to allow comparison of data from different sources. Support the creation applications in support of research projects. Collaborates with program staff on the design and analysis of biostatistics aspects of research protocols. Participates in the design of questionnaires and interview forms. Analyzes data beginning with univariate and multivariate analyses such as logistic regression and factor analysis for research studies. Supports the interpretation and assist in the creation of study results in collaboration with faculty members, epidemiologists, biostatisticians and other team members. Provides tabular and graphic summaries of analyses in a form suitable for inclusion in manuscripts for publication in peer reviewed scientific journals as well as for presentation at scientific meetings. Required Qualifications: Master's degree required in Computational Biology, Bioinformatics, or related field; Doctoral degree preferred. 3-5 years related work experience required. Demonstrated ability to integrate multiple complex datasets including RNA-Seq transcriptional profiles, ChIP-Seq and whole genome methylomes. Must be able to existing algorithms in the analysis of such data and, if necessary, derive novel programs. Ability to conduct and interpret multivariable regression analysis, ChIP peak calling, computational motif finding and other whole genome analyses. Advanced skills with Microsoft applications which may include Outlook, Word, Excel, PowerPoint or Access and other web-based applications. May produce complex documents, perform analysis and maintain databases. Competencies: Written Communications: Ability to summarize and communicate in English moderately complex information in varied written formats to internal and external customers. Oral Communications: Ability to comprehend and converse in English to communicate effectively with medical center staff, patients, families and external customers. Knowledge: Ability to demonstrate in-depth knowledge of concepts, practices and policies with the ability to use them in complex varied situations. Team Work: Ability to act as a team leader for small projects or work groups, creating a collaborative and respectful team environment and improving workflows. Results may impact the operations of one or more departments. Customer Service: Ability to provide a high level of customer service to patients, visitors, staff and external customers in a professional, service-oriented, respectful manner using skills in active listening and problem solving. Ability to remain calm in stressful situations. Physical Nature of the Job: Sedentary work: Exerting up to 10 pounds of force occasionally in carrying, lifting, pushing, pulling objects. Sitting most of the time, with walking and standing required only occasionally

Keywords: Beth Israel Deaconess Medical Center, Boston , Bioinformatician, Other , Boston, Massachusetts

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