Research Scientist I, PRISM

Company: Broad Institute
Location: Cambridge
Posted on: January 17, 2020

Job Description:

JOB DESCRIPTION

The Broad Institute is looking for an exceptional candidate for a Research Scientist I position in the PRISM group of the Cancer Program. This position affords the exciting opportunity to join our multidisciplinary team to develop new models and technologies for cell-based screening.



We seek an energetic and motivated individual to join the PRISM team to contribute their expertise to multiple ongoing and future collaborative projects and be a key thought leader for PRISM and across the Broad Cancer Program. The PRISM technology allows us to routinely profile up to tens of thousands of small molecules against hundreds of cancer cell lines and has enabled data collection at an unprecedented scale. We are seeking a talented cell biologist to help develop the next generation of PRISM by adapting our screening technologies to enable characterization of complex models such as patient-derived 3D cultures and organoids, and to optimize cell-based assays to understand drug mechanism of action.



In this role, you will be expected to have a broad cell-culture background with experience in complex models. You will be extremely organized, have a high attention to detail and high quality standards. You will be able to design, execute, and interpret experiments as part of a team and need to have great communication and delegation skills.



The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area and provides the potential for your contributions to be used and recognized worldwide.



CHARACTERISTIC DUTIES

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Culture and characterization of 3D models and evaluating feasibility of models for drug-screening applications.
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Helping to develop, optimize, and execute cell-based assays to understand drug mechanism of action (e.g., drug-resistance screens).
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Applying molecular biology techniques to design and execution of technical development experiments for quantitation of cellular models in mixtures.
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Writing scientific papers and giving presentations at internal and external meetings.
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Actively mentoring and potentially supervising junior team members.

Qualifications

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Ph.D. degree in biology, cellular biology, cancer biology or a related discipline with 4+ years of research experience in a cancer cell biology lab.
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Extensive tissue culture experience with practical experience with 3D cultures.
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Practical experience with basic molecular and cellular biology techniques including PCR cloning, DNA and RNA extractions, cell-viability assays, and CRISPR and/or shRNA-mediated gene perturbation
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Must have a thorough understanding of genetics, genomics, and cell biology
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Ability to effectively interpret experimental data
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Previous experience in a collaborative team environment is critical for success.
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Excellent communication skills and the ability to interact professionally with all levels of staff and with internal departmental contacts, as well as external collaborators, in a fast-paced environment.
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Basic computer skills including Google Drive, Microsoft Excel, & Microsoft Word are required.



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Keywords: Broad Institute, Boston , Research Scientist I, PRISM, Other , Cambridge, Massachusetts