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Senior Associate Scientist

Company: Intellia Therapeutics
Location: Cambridge
Posted on: February 16, 2020

Job Description:

At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop potential cures. We bring new hope for people living with conditions including cancer, genetic disorders, viral infections, inflammatory disorders and many more.Intellia Therapeutics, Inc. Senior Associate Scientist 40 Erie Street, Cambridge, MA 02139Duties : Develop and execute liquid chromatography coupled to mass spectrometry (LC-MS) based bioanalytical methodologies to investigate, monitor, and quantify RNA and CRISPR/Cas9 based therapeutics in cell extracts, blood, and tissue-derived biological samples. Collaborate with development scientists on analytical methods and analyze complex samples comprised of proteins, nuclear acids, lipid nanoparticles (LNP), and viral material. Execute bioanalytical aspects of pharmacokinetics and pharmacodynamics studies. Analyze specimen of test articles and biomarkers, which includes quantitation of oligonucleotides of various sizes by LC-MS/MS and edited proteins levels and mutations. Collaborate with colleagues in in vivo pharmacology, formulations, RNA synthesis, and analytical development groups. Prioritize and conduct sample analysis and data review in support of RNA modification design, pharmacology, biodistribution and pharmacokinetics, and toxicology studies. Independently develop and execute novel mass spectrometry-based assays for detection of large RNA and metabolites. Independently develop and execute assays for characterization and quantitation of markers and surrogates for delivery efficacy of CRISPR/Cas9 therapeutic candidates. Communicate research and development findings with internal and external partners. Review and ensure quality of scientific data meets regulatory expectations.Requirements : Requires a Bachelor's degree in Biotechnology, Chemistry, Biochemistry, Biology, or a directly related field plus seven (7) years of laboratory environment experience.Must have at least two (2) years of experience in each of the following; - Knowledge of mass spectrometry - Knowledge of analytical separation techniques, such as liquid chromatography and electrophoresis - Knowledge of analytical detection methods, such as optical and mass spectrometric - Experience running complex assays on a routine basis - Experience with blood and tissue-borne biological samples - Experience with structural analysis software of oligonucleotides, peptides, proteins, or quantitation of small molecules - Experience with technical transfers of protocols and methodologies to contract research organizationsWill accept a Master's degree plus four (4) years of laboratory environment experience in lieu of Bachelor's plus seven (7) years of experience.Telecommuting :Position is in a fixed location based in Cambridge, MA office; However, telecommuting is occasionally allowed from a home office.40 hours per week. Day shift. Send resume to: ref. P15What Intellia Stands For:At Intellia, our mission is to develop potentially curative genome editing treatments that can positively transform the lives of people living with severe and life-threating diseases.We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.POSITION: Full-Time, Exempt EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Keywords: Intellia Therapeutics, Boston , Senior Associate Scientist, Other , Cambridge, Massachusetts

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