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Senior Scientist, AAV Vector Analytical Development

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treatand even cureseveral of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertexs continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

We are looking for a leader who brings enthusiasm, intellectual curiosity, scientific rigor and a desire to innovate new medicines for patients.

Key Responsibilities:

* Execute analytic strategy for release and characterization of AAV gene therapy vectors, efficiently and independently * Establish a team responsible for implementation of molecular and cell-based assay platforms to support rapid advancement of multiple programs * Accountable for the development of robust characterization assays for early stage AAV process development * Generate hypotheses and creative solutions to pursue Project goals, set new experimental directions, and overcome obstacles * Implementation of novel process analytical technologies, including automation and high-throughput screening * Effectively collaborate with a fully integrated team to facilitate the success of projects, as well as, assists other outside of own project with troubleshooting and methods development * Provides technical recommendations broadly within the company regarding own field and plays a key Project Role

Requirements:

* PhD in Biochemistry, Cell & Molecular Biology, Genetics or related discipline and greater than 5 years experience or Masters degree and 9+ years experience will be considered * Direct industry experience leading teams responsible for developing release assays and/or work in a Quality Control lab * Extensive practical knowledge of a broad range of analytic tools for quantification and characterization of AAV vectors * Experience contributing to CMC strategy through participation on global development team * Demonstrates advanced judgment balancing technical feasibility, opportunity, and impact * Demonstrates initiative and ability to capitalize on scientific creativity and insights * Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team

#LI-JS1

Keywords: Vertex Pharmaceuticals Inc (US), Boston , Senior Scientist, AAV Vector Analytical Development, Other , Boston, Massachusetts

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