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Senior Research Associate, Vector Analytical Development

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treatand even cureseveral of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertexs continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

KEY RESPONSIBILITIES

* Develop new test methods for characterization of strength, purity and specific classes of impurities * Execute test methods in support of AAV viral vector Process Development activities (e.g. viral genome titer, capsid titer, cell-based potency, SDS-PAGE, residual impurity characterization) * Troubleshoot, optimize, and trend assay performance * Report on project progress, contribute to analytical development protocols and reports, provide technical recommendations to management * Transfer assays to QC and provide SME support for assay qualification, author and review transfer/qualification protocols and reports * Maintain excellent written documentation (e.g. lab notebook and test forms).

REQUIREMENTS

* A Masters degree in Biochemistry, Cell & Molecular Biology, Genetics or related discipline and 0 to 2 years experience, or Bachelors degree and 3 to 5 years experience * Hands-on experience with the following assays: ddPCR, qPCR, RT-qPCR, SDS-PAGE, ELISA, Western blots and cell- based potency assays * Experience with sample management and ELN/LIMS systems * Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team * Experience working with viral vectors for gene therapy and with contract research or manufacturing organizations is preferred

Keywords: Vertex Pharmaceuticals Inc (US), Boston , Senior Research Associate, Vector Analytical Development, Other , Boston, Massachusetts

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