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Scientist, Chromatography

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

Position Overview:

Vertex is seeking a talented individual to join our Analytical Development group in Boston, MA. This role will support the drug development programs at Vertex as a member of the chromatography Subject Matter Expert (SME) team. The chromatography SME team is responsible for the development of HPLC methods required for Drug Substance and Drug Product across all Vertex clinical programs, utilizing statistical design of experiment approaches (DoE) and in-silico tools to identify the most robust operating space. Strong skills in sample preparation are required. Hands-on experimental work is required. The ability to work both independently and in a matrix team environment is essential. Expertise in laboratory techniques commonly used in the analysis of pharmaceutical products, especially HPLC and MS, are required.

Key Responsibilities include but are not limited to: - Develop methods to determine potency, purity, and stability for drug substances (DS) and/or drug products (DP) - Designs, executes, and interprets experiments with a high degree of reliability, independence, and attention to detail - Maintains accurate records of experiments and results in a laboratory notebook and authors reports as assigned- Utilizes software tools (Fusion QbD, DryLab, etc.) to model experimental design space in order to identify a robust operating region - Maintains general lab equipment, including HPLCs - Develops sample preparation procedures suitable for quantitative analyses - Troubleshoots issues encountered with final DS and DP HPLC methods Basic Qualifications A Masters degree or Ph.D. in the life or physical sciences with a preference for a concentration in Analytical Chemistry - Minimum Experience: Ph.D. (0-2 years), Masters (2-5 years) current and relevant industry experience working in drug substance and drug product support (preferably small molecule) - An in-depth knowledge of HPLC, including both theory and practice, is required. - Familiarity with alternate chromatography modes including ion chromatography, HILIC, chiral, and supercritical fluid chromatography is preferred. - An understanding of statistical design of experiment approaches is preferred - The ability to work successfully in both a team/matrix environment as well as independently is essential - The ability to work in a fast pace environment, manage priorities, and maintain timelines for multiple projects is essential - Excellent written and verbal communication skills

Keywords: Vertex Pharmaceuticals Inc (US), Boston , Scientist, Chromatography, Other , Boston, Massachusetts

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