BostonRecruiter Since 2001
the smart solution for Boston jobs

Vector Synthesis Senior Research Scientist

Company: Vertex Pharmaceuticals Inc (US)
Location: Boston
Posted on: September 17, 2020

Job Description:

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treatand even cureseveral of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertexs continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

The Vector Synthesis Team will be responsible for assembling novel gene therapy and plasmid vectors in the new Genetic Therapies Research unit of Vertex Pharmaceuticals.

Responsibilities :

* The Senior Scientist is responsible for the synthesis, quality control, and production of novel plasmid DNA molecules to be used in therapeutic, CMC, and analytical applications. * Demonstrate an excellent understanding of nucleic acid enzymology and biology and strong experience engineering novel DNA sequences for experimental and/or therapeutic applications in mammalian systems. * Lead and participate in cross-functional genetic therapies teams across Vertex, to advance our understanding of the science of gene therapy vector manufacture and performance.

Minimum Qualifications

* Ph.D. in recombinant molecular biology intensive field * At least 6 years of experience in mammalian gene expression cassette design, synthesis, and testing * Experience in recombinant DNA assembly methodology, including Gibson Assembly, PCR, conventional restriction enzyme digestion & ligation, and facilitated recombination (i.e., Gateway cloning) methodology * Experience leading and managing laboratory scientists and technicians * Strong cross-functional leadership skills including refined verbal and written communication skills * Strong computational skills and experience with a broad spectrum of DNA sequence analysis tools

Preferred Qualifications

* Experience with engineering cell lines for a variety of purposes using both random and targeted molecular techniques * Chromatographic purification of biological molecules * Experience working with difficult to propagate and large (>20 kbp) plasmid sequences in E. coli * Direct experience designing and building rAAV-based viral gene therapy vectors * Experience with microbial fermentation for production of bacterial plasmids * Python, Perl, and linux scripting proficiency, in particular as relates to processing of large sequencing data sets * Experience in biologics production and/or QC * Experience with a wide variety of next generation sequencing library construction methodologies

#LI-JS1

Keywords: Vertex Pharmaceuticals Inc (US), Boston , Vector Synthesis Senior Research Scientist, Other , Boston, Massachusetts

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Other Jobs


Explosive Ordnance Disposal Technician
Description: ABOUT Explosive Ordnance Disposal EOD Technicians have expertise in the most conventional and unconventional explosives to ensure the secure disposal of explosive weaponry. They are on call to respond (more...)
Company: Navy
Location: Woonsocket
Posted on: 09/22/2020

Delivery Coordinator (Immediate Openings)
Description: Shifts: Early Morning, Day, Evening Location: Milford, MA Job opportunities vary by location. We update postings daily with open positions. Hourly Pay Rate 15.75/hr - 18.75/hr , plus (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/22/2020

Nuclear Operations
Description: ABOUT Nuclear technicians, power plant operators and subsystems specialists are responsible for keeping vital Naval submarines and aircraft carriers running. These highly trained, hands-on professionals (more...)
Company: Navy
Location: Woonsocket
Posted on: 09/22/2020


Principal Software Engineer
Description: Company: The Ascent Services Group, Inc Location: Littleton Posted on: September 12, 2020 Job Description: Job ID: 20-4667 Title: Principal Software Engineer Location: Littleton, CO Type: Direct (more...)
Company: Amazon Workforce Staffing
Location: Woonsocket
Posted on: 09/22/2020

Full-time Warehouse Team Member - $500 sign-on bonus
Description: Full-time Warehouse Team Member - 500 sign-on bonus Hourly pay rate: Earn 15.75 - 18.75/hr, plus benefits and a 500 sign-on bonus. Limited-Time Opportunity Location: Taunton, MA (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/22/2020

Warehouse WorkerAmazon Warehouse Assistant - Different Shifts Available - Earn$15.75/hr or more
Description: Shifts: Early Morning, Day, Evening Location: Milford, MA Job opportunities vary by location. We update postings daily with open positions. Hourly Pay Rate 15.75/hr - 18.75/hr , plus (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/22/2020

Finance Director
Description: Company: Amazon Workforce Staffing Location: Woonsocket Posted on: September 17, 2020 Job Description: Company: Michael Page International GmbH Location: Cambridge Posted on: September 12, 2020 (more...)
Company: Amazon Workforce Staffing
Location: Woonsocket
Posted on: 09/22/2020

Special Warfare Combatant-Craft Crewmen
Description: ABOUT Special Warfare Combatant-Craft Crewmen SWCC are specially trained to operate on and around rivers and coastal regions around the world. Wielding extreme firepower and a deadly skill set, SWCC (more...)
Company: Navy
Location: Woonsocket
Posted on: 09/22/2020

Delivery CoordinatorAmazon Warehouse Assistant - Different Shifts Available
Description: Shifts: Early Morning, Day, Evening Location: Milford, MA Job opportunities vary by location. We update postings daily with open positions. Hourly Pay Rate 15.75/hr - 18.75/hr , plus (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/22/2020

Medical Support
Description: ABOUT Medical emergencies happen and we need people who can take charge when they do. Whether you're in a hospital or clinical setting, on a ship or submarine, or out in the field alongside fellow (more...)
Company: Navy
Location: Woonsocket
Posted on: 09/22/2020

Log In or Create An Account

Get the latest Massachusetts jobs by following @recnetMA on Twitter!

Boston RSS job feeds