Scientist

Company: Yoh, A Day & Zimmermann Company
Location: Brighton
Posted on: April 10, 2021

Job Description:

Location: Waltham, MA

Position Summary:

Client is a startup biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as a Scientist, supporting our novel target identification and validation workflow in house. The ideal candidate should have relevant experience in primary T cell culture, immunoassays, flow cytometry, and molecular biology, and enjoy fast-paced, collaborative and vibrant startup culture. A team player with a sense of urgency will thrive in this role.

Duties of position:
------- Engage and innovate on large-scale in vitro immune cell screening efforts to discover novel TCRs to fuel our therapeutic pipeline.
------- Isolate PBMCs, primary T cells, and monocytes from blood products such as leukopaks, differentiate monocytes to DCs, and perform T cell-DC co culture assays.
------- Evaluate and nominate candidate TCRs discovered from our screens for preclinical development. Candidate to perform in vitro immune assays such as tumor cell killing, cytokine production and T cell proliferation.
------- Evaluate novel targets to be pursued in TCR discovery pipeline, and assist in platform development for discovery of TCRs specific for multiple targets.
------- Candidate to analyze data and present and group and company meetings.
Requirements:
------- Ph.D. with 0-2 years of relevant post-doc, biopharmaceutical or biotechnology industry experience, or MS/BS with 7-10 years relevant experience. Demonstrated record of scientific achievement (strong publication and/or patent record).
------- Extensive experience in T cell immunology required; understanding of dendritic cell biology, cancer biology and molecular biology a plus.
------- Expertise in tissue culture, flow cytometry, and cell engineering required. Proficiency in immunological techniques such as ELISA and cytotoxicity assays using Incucyte desired.
------- Excellent communication skills (both written and oral) and ability to work in a matrix environment.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.PandoLogic. Keywords: Cell Biologist, Location: Brighton, MA - 02135

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