Postdoctoral Fellow

Company: Massachusetts General Hospital
Location: Boston
Posted on: June 12, 2021

Job Description:

Postdoctoral Fellowship in the Laboratory of Neurodegeneration, Neurodiscovery and Neurotherapeutics

We are seeking a post-doctoral fellow to join the Chopra/Rosas lab in the Department of Neurology at the Massachusetts General Hospital MIND Center, Harvard Medical School. Under the mentorship of Drs. Chopra, PhD and H. Diana Rosas, MD, the lab uses and develops techniques and approaches to identify blood and CSF biomarkers from human samples for the determination of key factors that determine onset and/or progression in Huntington's disease and in Alzheimer's disease in Down syndrome. Insights from these studies are then used to further investigate salient and key pathological mechanisms that underlie phenotypic variation and neurodegeneration.

The position requires experience in RNA / DNA extraction, RNA sequencing and digital PCR. Skills in experimental design, protocol development, and troubleshooting is required. Responsibilities include design and execute next generation sequencing experiments to identify and characterize long noncoding RNA in patients biofluids & postmortem brain samples and oversee our ongoing studies on identification of small molecules using reverse phase chromatography. The applicant will combine transcriptomics and metabolomics data to identify the pathways responsible for disease progression. Our studies are funded by the National Institutes of Health.

Requirements: Applicants must have a PhD (or equivalent doctoral degree) in neuroscience, molecular biology, biochemistry or a related field, from an accredited institution. Fellows must receive their degree by the start of training or have received their degree no more than four years ago. Candidates must be a US citizen or be eligible to work in the United States (after obtaining an appropriate visa).

Desired skills: Strong candidates should have prior experience with the isolation of small molecules and development of analytical methods using High-Performance Liquid Chromatography; this is preferred but not required. Candidates should have excellent organizational and problem-solving skills, ability to play, prioritize and keep multiple projects/tasks moving forward simultaneously. A strong track record of documented productivity a plus. We are seeking highly motivated candidates with strong writing, communication, analytical, and problem-solving skills. Candidates should also have proficient writing skills and have demonstrated ability to complete projects as evidenced by first author publication(s).

Interested candidates should email a cover letter briefly describing their research interests and qualifications, a curriculum vitae, as well as the names and contact information for three references to Dr. H. Diana Rosas at: rosas@helix.mgh.harvard.edu. Applications will be reviewed on an ongoing basis. Salary will be competitive and commensurate with experience.

Keywords: Massachusetts General Hospital, Boston , Postdoctoral Fellow, Other , Boston, Massachusetts