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Associate Scientist II/Senior Associate Scientist, Process Development (Downstream Focus) (Contract)

Company: Voyager Therapeutics
Location: Lexington
Posted on: June 12, 2021

Job Description:

Reports To

Scientist II

We are Voyager Therapeutics, a company compelled by curiosity and powered by persistence. We are the seekers who specialize in clinical-stage gene therapy, focused on developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV gene therapy through innovation in vector engineering, capsid discovery, manufacturing, and the optimization of dosing and delivery to enable these novel therapies. Our wholly owned and partnered pipeline focuses on severe neurological diseases, such as Parkinson's disease, Huntington's disease, Friedreich's Ataxia and other areas where patient communities are currently underserved. We've been busy, but we've got so much more to discover - such is the life of a Voyager.

If you're someone who thrives on finding the elusive answers to tough questions, come explore with us!

Voyager is seeking a highly motivated Senior Associate Scientist/Associate Scientist to join the Process Development Group with a focus on downstream purification. The qualified candidate will have a strong background and expertise in downstream manufacturing of biologics. Primary responsibilities will include carrying out downstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in internal productions, writing documents, and assisting with technology transfer activities. The ability to independently organize and design experiments, analyze data and report the results of their and other's work in a concise and well documented manner are all important aspects of the position. This is a 12 month contract position.

Responsibilities

  • Perform benchtop and preparative separations of rAAV particles using various separation and chromatographic techniques
  • Develop purification protocols for viral capsids using column chromatography / AKTA protein purification systems
  • Complete concentration and diafiltration operations using Tangential Flow Filtration
  • Carryout Pmax and Vmax studies for depth and sterile filtration development
  • Prepare reagents and solutions required for production protocols
  • Assist with the production of nonclinical materials at Voyager
  • Maintain and update various databases and electronic notebook entries, as needed
  • Participate in writing various experimental reports, SOPs, batch records, and technology transfer documents.

Minimum Qualifications

  • BS in related discipline with 1-5 years of relevant experience OR MS in related discipline with 0-4 years of relevant experience
  • Previous experience in downstream purification of biotherapeutics
  • Experience with purification techniques, including the use of AKTA systems, TFF systems, and cell filtration devices is desired
  • Familiarity with high-throughput chromatography applications is a plus
  • Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required
  • Significant attention to detail and accuracy in developing and following protocols
  • Ability to be highly productive in a fluid, fast-paced and teamwork environment

RECRUITING & STAFFING AGENCIES: Voyager Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Voyager or its employees is strictly prohibited unless contacted directly by Voyager's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Voyager, and Voyager will not owe any referral or other fees with respect thereto.

Keywords: Voyager Therapeutics, Boston , Associate Scientist II/Senior Associate Scientist, Process Development (Downstream Focus) (Contract), Other , Lexington, Massachusetts

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