Genomic Core Manager (Talkowski Lab)
Company: Massachusetts General Hospital
Posted on: June 13, 2021
GENERAL SUMMARY/ OVERVIEW STATEMENT:
The Talkowski Laboratory in the Center for Genomic Medicine
(CGM) at Massachusetts General Hospital (MGH) and the Broad
Institute of MIT and Harvard is seeking a motivated, enthusiastic,
experienced staff scientist to lead the CGM Genomics and Technology
Core (GTC). The GTC is the primary genomics hub for the CGM, which
encompasses 46 faculty engaged in all facets of human genetics and
genomics research. The GTC is committed to the development and
application of innovations in genomics methods for exome, genome,
transcriptome, epigenome, and multiple other 'omics technologies.
The GTC provides all genomics research solutions, including
molecular genomics and bioinformatics support, for CGM faculty and
research programs within and outside the MGH, Harvard Medical
School, and Broad Institute Communities. The candidate will lead
the GTC and oversee the genomics programs within the Talkowski
laboratory, which will include personnel management and training,
project and program management, budget management, development and
maintenance of standardized protocols and processes, as well as
widespread interactions with faculty across our communities and
institutions. Exceptional candidates will have extensive experience
in genomics technology development and library production, in
addition to outstanding organizational, interpersonal, and
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Laboratory Training and Leadership:
- Supervise molecular genetics technicians and/or staff
scientists to generate libraries and data using state-of-the-art
genomics methods and technologies.
- Coordinate with faculty, project leaders, and team members to
ensure proper integration of data and workflow.
- Train staff on new and existing techniques and protocols.
- Closely integrate and coordinate with the Broad Institute
- Manage personnel including training, assignments and schedules
to meet milestones and deadlines.
- Manage submissions and create projections of data generation
needs, timelines, and costs.
- Manage all equipment and consumable purchasing and
- Maintain laboratory notebook.
- Maintain project records.
- Perform basic analysis of genomics library metrics in tandem
with the GTC Bioinformatics team.
- Prepare and present reports to PI and lab members.
Development and Execution of Experimental Protocols:
- Must be experienced with the handling and manipulation of
biological samples (e.g., tissue, blood, cells) from a variety of
specimens (e.g., human, mouse, invertebrates).
- Perform and oversee high quality library generation for
- Determine most suitable methodology and protocols for proposed
- Design, modify, and standardize protocols based on state-of-the
art techniques and current literature.
- Troubleshoot problems with experiments, protocols, and
- Generate cost projections and timelines for experiments and
- Oversee project billing.
- Establish and maintain annual and quarterly GTC budgets in
coordination with CGM Finance Management team.
- Prepare written and/or verbal financial reports.
Participation in Publication:
- Perform independent literature searches.
- Prepare written and/or verbal status reports.
- Organize materials and analyze data for publication or
- Draft materials for the preparation of research presentations,
manuscripts and grants.
- Ph.D. in biological field required
- At least 5 years of post-graduate experience required.
- Extensive expertise (5 years) in molecular biology techniques
(e.g., PCR, qPCR, gel electrophoresis, DNA/RNA extraction
- Extensive expertise (5 years) in genomics library generation
(e.g., genome, exome, RNA-seq, amplicon-seq, capture-seq, ATAC-seq,
ChIP-seq, scRNA-seq) and sequencing methods (e.g., Sanger,
Illumina, PacBio, ONT).
- Ability to troubleshoot library construction and sequencing
results (e.g., experience with basic analysis including R, Unix
environment, GATK pipeline).
- Ability to work independently and as a team member.
- Ability to prioritize tasks, set deadlines, and adapt to
shifting priorities in response to changing deadlines and needs of
- Ability to function with speed, precision, and an understanding
of theory behind protocols and experiments.
- Excellent organizational and communication skills.
- Outstanding interpersonal skills and the ability to supervise
and train scientific staff.
SUPERVISORY RESPONSIBILITY (if applicable):
- May supervise 2 or more Laboratory Assistants, Technicians,
Technologists, and/or staff scientists.
FISCAL RESPONSIBILITY (if applicable):
LICENSES, CERTIFICATIONS, and/or REGISTRATIONS (if
Work will be performed in the Simches Research Building on the
MGH main campus in Boston, MA.
Keywords: Massachusetts General Hospital, Boston , Genomic Core Manager (Talkowski Lab), Other , Boston, Massachusetts
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