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Cellular Biodistribution Scientist

Company: Takeda Pharmaceutical
Location: Boston
Posted on: May 16, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionOBJECTIVESAs part of a team, in this role a successful candidate will provide laboratory based cellular biodistribution support to the global Drug Metabolism and Pharmacokinetics contribution to preclinical discovery and development programs in support of Takeda portfolio. This role will be responsible for executing DMPK deliverables to propel assets from discovery to development and subsequently through registration.ACCOUNTABILITIES:Develop the capabilities needed to evaluate the microbiodistribution of diverse modalities, including but not limited to lipid nanoparticles, viral vectors, peptides, oligos, antibody conjugates, and cell therapies. Provides biodistribution support and scientific development techniques to support all pre-IND efforts in our Rare Diseases and Oncology Drug Discovery Units (DDUs) and all post-IND studies for all Takeda Therapeutic Area Units (TAUs), GI, Neuroscience, Oncology and Rare Diseases. Plans and executes high quality in vitro and or in vivo biodistribution assessments to understand and quantify the distribution of diverse novel modalities. Collaborate with global DMPK teams associated with micro and macro distribution/pharmacokinetics and pharmacodynamic response assessments to guide project teams in evaluating preclinical assets. May mentor/develop scientists in biodistribution techniques. Proactively engages with emerging technologies, participates in consortia for investigation of evolving technologies, and conducts research to improve capabilities and understanding of diverse modality disposition. Has knowledge of how to optimally execute outsourcing models for DMPK to balance internal and external workload in the study biodistribution of molecules. Builds LC-MS/MS, microscopy, PCR, ELISA, and flow-based strategies to enable assessment and quality for successful asset development. Partners with DMPK project representatives and leaders with whom he/she will collaboratively guide and influence to achieve clarity on issues, executing the work plans and providing decision-making results. Establishes, communicates, and executes plans resulting in advancement of Takeda's portfolio by Timely completion of studies while maintaining high quality standards; Managing project timelines considering risk, cost, and benefit to Takeda; and Working within cross-functional individuals in relevant communications, decisions and working groups as appropriate.EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:Ph.D. in Microbiology, Biochemistry, Pharmacology and/or Pharmaceutical Sciences or MS with 6-8+ years relevant experience, or BS with 8-10+ years relevant experience. Hands-on laboratory experience in the evaluation of cellular biodistribution with primary cell culture, 3-D systems, and co-cultures. Expertise in LC/MS, microscopy, PCR, ELISA, and flow-based instrumentation (FACS, Flow Cytomtery) and experience with developing LC/MS/MS, microscopy, PCR, ELISA, and flow-based assessments. Newer techniques like in situ hybridization, spatial transcriptome, and exosome sequencing are a plus. Understanding of clinical relevance of biodistribution of diverse modalities and contextualizing this data in conjunction with other assessments of efficacy. Record of insightful publications contributing to aspects of disposition and microdistribution. Experience in collaboration and mentorship with scientists and associates The candidate must be a team player with excellent communication/interpersonal skills. Proven ability to work independently and handle effectively multiple projects Ability to articulate and establish processes that have cross-functional impact and drive decision-making within a cross-functional team structure Ability to work in a virtual setting/across time-zones, i.e., making effective use of communication tools (WebEx, Telepresence, telephone and video conferencing, etc.) Management of multiple tasks of varied complexity simultaneously Excellent organizational skills Effective presentation skills - create and deliver presentations with appropriate messaging and focused recommendationsTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.WHAT TAKEDA CAN OFFER YOU:401(k) with company match and Annual Retirement Contribution Plan Tuition reimbursement Company match of charitable contributions Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs Empowering Our People to ShineIn accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Boston , Cellular Biodistribution Scientist, Other , Boston, Massachusetts

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