Scientist/Senior Scientist, Quantitative Biology
Company: Entrada Therapeutics
Location: Boston
Posted on: May 16, 2022
Job Description:
Job DescriptionThe OrganizationWhat's happening at Entrada
Therapeutics? Our mission is to transform the treatment of
devastating diseases and improve patients' quality of life using
intracellular biologics. Leveraging our proprietary Endosomal
Escape Vehicle (EEV)™ platform, we are creating and advancing a
diverse pipeline of oligonucleotide, enzyme, protein and peptide
programs to efficiently target and engage underlying drivers of
diseases.Our novel approach to drug design and delivery addresses
current challenges associated with both large and small molecule
therapeutics and represents a fundamental advancement in the field
of intracellular biologics.We're a tight-knit team of experts and
leaders in both therapeutics development and rare disease and are
excited to grow and attract colleagues who are ready to join a high
energy, dedicated team that likes to get things done and
dramatically improve the lives of patients and their families.The
Perfect FitYou should be versatile, self-motivated, and looking
forward to rolling up your sleeves, as you will be involved in all
aspects of biomarker development. Your team player mentality and
excellent communication skills will allow you to collaborate
effectively as you work alongside your team as well as
cross-functionally.The OpportunityIn this position you will be
responsible for designing, optimizing, and qualifying Biomarker
assays for RNA targets. You will support our drug discovery and
other teams as we develop oligonucleotide-based pipelines to treat
some of the world's most challenging diseases.Responsibilities
- Developing and executing RNA-based assays for validating
biological activity of oligonucleotide therapeutics in vivo and in
vitro
- Process and analyze samples from in vitro and in vivo PK/PD
studies
- Develop new assays in support of RNA Biomarker development
- Prepare SOPs and other reports for assay development and
qualification
- Function and communicate effectively in a highly dynamic and
cross-disciplinary environment and serve as a liaison between teams
and program
- Carefully document experiments in an electronic lab notebook
and communicate results across teams
- Effectively communicate your work in meetings, interpret and
present research data and findings, contribute to patents, reports,
and scientific publications.The NecessitiesAt Entrada, our passion
for science, our devotion to patients and our values drive our
behavior:
- Humanity - We genuinely care about patients and about one
another.
- Tenacity - We are relentless and persistent in the pursuit of
developing therapies for patients.
- Creativity - We are creative problem solvers.
- Collaboration - We are more than the sum of our parts.
- Curiosity - We have a growth mindset and push conventional
thought and theory.To thrive on our team, you will need to come
with:
- Ph.D. in biochemistry, biology, or a related field along with
1-3 years post-degree experience laboratory research experience in
industry or academic setting
- Hands-on experience in cellular and molecular biology
techniques including RNA extraction, RT-PCR, qPCR, ddPCR and assay
development
- Strong background in oligonucleotides therapeutics is
preferred
- Experience with designing effective splice-switching antisense
oligonucleotides for exon skipping and exon inclusion. It would
also help to have experience in Next Generation RNA sequencing
techniques, but by no means is it mandatory
- To be effective on our team, we need you to have excellent
communication skills and thrive in collaborative environments
- We are solving tough problems, so we would love to hear about
how you have tackled this in the past
- Entrada's a fast-paced environment, so being able to multitask
to help us meet our research and development goals would be
necessary
- We like to have fun too, so a positive attitude is a must
have!The PerksBy becoming a team member here at Entrada, you'll
have access to competitive health, dental, and vision coverage, as
well as life insurance, and short term and long-term disability
insurance. We value work life balance, you'll benefit from
discretionary time off, paternity leave, and an excellent 401(k)
package. We also offer a generous transportation stipend to commute
as you wish. Our location in the vibrant and growing Seaport
District is close to all the best that the city of Boston has to
offer.Entrada Therapeutics is an equal opportunity employer.
Qualified candidates will receive consideration for employment
without regard to race, color, religion, national origin, gender,
sexual orientation, gender identity or expression, age, mental or
physical disability, and genetic information, marital status,
citizenship status, military status, protected veteran status or
any other category protected by law.Third Party Staffing
AgenciesEntrada does not accept unsolicited resumes from any source
other than directly from candidates. For the protection of all
parties involved in the recruiting process, resumes will only be
accepted from recruiters/agencies if a signed agreement is in place
at the inception of the recruiting effort and authorized for a
specified position. Unsolicited resumes sent to Entrada from
recruiters/agencies do not constitute any type of relationship
between the recruiter/agency and Entrada and do not obligate
Entrada to pay fees if we hire from those resumes.Powered by
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Keywords: Entrada Therapeutics, Boston , Scientist/Senior Scientist, Quantitative Biology, Other , Boston, Massachusetts
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