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Senior Scientist, Computational Biology

Company: Takeda Pharmaceutical
Location: Southborough
Posted on: September 25, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Senior Scientist where you will be part of a computational team focused on utilizing computational and systems biology approaches to analyze multi-omics data supporting Takeda drug discovery and development projects and apply expertise in bioinformatics, genomics, machine learning and computational biology to integrate and analyze multiple types of omics data, to evaluate in vitro and in vivo toxicity and DMPK models, associate to safety and efficacy characterizations, and generate biomarker hypotheses.You will also work closely with colleagues from preclinical and translational science organization, including Drug Metabolism & Pharmacokinetics, Drug Safety Research & Evaluation, Genetics and Systems Biology, Quantitative Solutions, and Clinical Biomarker Innovation & Development. As part of the Computational Biology team, you will report to the Director Computational Biology. How you will contribute:

  • Collaborate with Takeda colleagues to evaluate and prioritize in vitro and in vivo models for drug metabolism & Pharmacokinetics efforts.
  • Method development for and evaluation of integrating multi-types of omics data.
  • Identify, build, and use bioinformatic pipelines to QC omics data types including genomics, transcriptomics (RNAseq, scRNAseq and spatial transcriptomics), proteomics, and other omics data.
  • Select and apply various computational biology methods based on project needs, including systems biology, pathway/network analysis, machine learning, and artificial intelligence.
  • Interact closely with biologists to conduct analyses, data integration and data interpretation.
  • Analyze preclinical and clinical data using appropriate computational and statistical methods.
  • Create visualizations, interpret high dimensional data and explain results to cross-functional teams.
  • Plan and coordinate computational biology activities internally and in partnership with external CROs and academic partners, including complex projects requiring collaboration with multiple members of the team and organizations.
  • Prepare and present comprehensive scientific reports to a full range of internal and external audiences.
  • Work collaboratively with data scientists and data engineering groups to enhance our computational infrastructure, user interface, query and visualization capabilities.
  • Writes study reports and presents data effectively in all settings and with participants of all levels of the organization. Minimum Requirements/Qualifications:
    • PhD degree in a scientific discipline, with 3+ years' experience, or
    • MS with 9+ years' experience, or
    • BS with 11+ years' experience
    • Previous industry experience, preferably with big pharmaceutical companies and on clinical programs. What Takeda can offer you:
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Keywords: Takeda Pharmaceutical, Boston , Senior Scientist, Computational Biology, Other , Southborough, Massachusetts

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