Head of Discovery and Development ADME Characterization DMPK

Company: Takeda Pharmaceuticals International GmbH
Location: Boston
Posted on: January 26, 2023

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:

• The head of ADME characterization will be a member of global senior leadership in DMPK and work closely with the senior management of Research, peers and project teams to deliver quality molecules, regardless of modality, through clinical development, with responsibility to build and deliver quality ADME regulatory packages.
• Directly lead and manage the in vitro ADME group to provide radiochemistry, enzymology, transporter, and metabolite identification related activities and expertise to discovery and development projects.
• Oversee preparation of the regulatory related document submission.
• Provide strategy, career development opportunities, and daily oversight of personnel within ADME functions (Enzymology, Cellular distribution, transporters, Biotransformation/MetID, and Radiochemistry)
• Work with other global and local DMPK managers to reinforce and modify the DMPK strategy and operational model to ensure future scientific successJoin Takeda as the Head of Discovery & Development ADME Characterization DMPK, based in Cambridge, MA.How you will contribute:ACCOUNTABILITIES
  • Accountable for the delivery of ADME packages to regulatory submission and response to regulatory agencies in scientific related ADME querries.
  • Inspirationally leads, directs, oversees, coaches, develops, and motivates all DMPK scientists and staff
  • Develops novel paradigms and techniques supporting ADME characterization to improve the success rate of pre-clinical candidates and advances them through clinical development and regulatory filing for unmet medical needs of patients.
  • Develops and implements an overall vision for the DMPK group that is consistent with the mission and strategic objectives of Takeda drug discovery, development and core sciences
  • Partners with senior leaders in the drug discovery and development to ensure alignment, management and delivery of drug milestones.
  • Ensures all data package content aligned with Takeda affiliate needs, both internal and partnered programs
  • Provides deep strategic leadership within the group
  • Directs and integrates departmental activities to ensure individual drug discovery and development project objectives are met
  • Plays a key role in creating and maintaining a nurturing research environment that encourages creativity, collaboration among scientists from different disciplines and organizations, and efficient utilization of resources.
  • Proactively seeks out new impacting technologies and incorporates them into the company.
  • Directs and integrates departmental activities to ensure the ADME science objectives are met
  • Plays a significant leadership role in the management of cross-functional research activities that contribute to drug discovery and development efforts
  • Is responsible for the direct line management of the department team leaders and is accountable for their performance and career development
  • Provides motivation/inspiration to colleagues and consistently communicates with scientists inside and outside the department to plan and optimize workflows
  • Is responsible for setting and meeting department goals
  • Initiates external collaborative arrangements and evaluations as required
  • Responsible for creating the department budget and adhering to it in accordance with Takeda policy
  • Coordinates the evaluation and review of data, the determination of problem solutions, project priorities and future strategies in multidisciplinary settings
  • Has a demonstrated ability to successfully direct multiple projects simultaneouslyMinimum Requirements/Qualifications:
    • Ph.D. in Analytical Chemistry, Chemistry, Pharmacokinetics, Pharmaceutical Sciences, Bioanalytical Chemistry or a related field and a minimum of 15 years industry experience in a related field OR
    • M.S. in Analytical Chemistry, Chemistry, Pharmacokinetics, Pharmaceutical Sciences, Bioanalytical Chemistry or a related field and a minimum of 21 years industry experience in a related field OR
    • B.S. in Analytical Chemistry, Chemistry, Pharmacokinetics, Pharmaceutical Sciences, Bioanalytical Chemistry or a related field and a minimum of 23 years industry experience in a related field
    • Has demonstrated independent thought/creativity in science and success in coordinating and executing research to further corporate goals
    • Is an acknowledged expert in the field of analytical chemistry, mass spectrometry, Drug Metabolism/Transporter and/or DMPK
    • Leadership experience of at least 9 years
    • Presents research strategies formally to Research Committee
    • Excellent communication and leadership skills
    • High multitasking capabilitiesWhat Takeda can offer you:
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

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