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Senior Scientist, Biochemistry, Biophysics, Protein Sciences

Company: PharmaEssentia U.S.A.
Location: Burlington
Posted on: May 28, 2023

Job Description:

Job summary:The PharmaEssentia Innovation Research Center is building a world-class new drug discovery team in Boston area. PharmaEssentia strives to develop first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and antibody-drug-conjugates, with a novel mechanism of action. To this end, we are seeking a highly motivated and experienced biologics characterization, expression, and purification scientist to join our Biologics Platform team. The successful candidate will be responsible for generating and characterizing novel protein biotherapeutics such as engineered cytokines, mono- or bi-specific antibodies, or multi-functional fusion proteins. The successful candidate should possess extensive knowledge and experience in mammalian protein production and protein analytical methods. -The Company:It's not often you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You'll find that rare opportunity at PharmaEssentia. Join us, and let's transform lives, together.PharmaEssentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology, oncology and immunology, with one approved product and a diversifying pipeline. We believe in the potential to improve both health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking.Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung. -Our new research center, PharmaEssentia Innovation Research Center (PIRC), will build upon our invention and discovery-based innovation efforts originally established in Taiwan that led to a transformative advancement for treating polycythemia vera (one of myeloid proliferative neoplasm). At PIRC, we aim to expand our current expertise in related therapeutic areas and identify novel therapeutic approaches in early to mid-stage discovery and development. Data scientists will leverage artificial intelligence and machine learning to inform new target and indication selections. The company is also recruiting for talented scientists who have deep knowledge in immunology, translational science, bioinformatics and biologics platform in developing novel drugs employing disease-driving biology, novel technology in protein engineering, antibody discovery and new modality. Summary of Key Responsibilities: -

Express and purify recombinant protein (cytokines), antibodies, and antigens in mammalian cell culture and other expression systems (internal activity). Coordinate with CRO or external partners to ensure timely delivery of data and material package (external activity). -Characterize the quality and physiochemical properties of candidate molecules using analytical and biophysical methods.Participate in project teams, identify and prioritize critical experiments to accelerate the drug discovery programs, and contribute to an innovative product portfolio with diverse modalities.Constantly assess and implement new technology to the existing workflow to improve efficiency and inspire creativity.Provide mentoring and training to new and junior colleagues.Essential Qualifications:
Ph.D. in biochemistry, analytical chemistry, or a related scientific discipline with 5+ years' experience, or B.S./M.S. with 10+ years' experience within a protein sciences or biologic discovery function.A minimum of 3 years of industry experience in hands-on analytical characterization of biologics is required.Expertise in protein analytical techniques such as UV-VIS, SEC-HPLC, RP-HPLC, CE-SDS, cIEF/IEX DLS, and DSF.Experience with transient and stable mammalian protein expression.Experience in protein purification using automated (AKTA) systems and purification of constructs with appropriate tags.Preferred Qualifications:
Strong hands-on experience in investigating protein-protein interactions using one or more biosensor-based platforms (Biacore, Octet) is highly preferred.Expression and purification of non-standard antibodies such as bi- and tri-specific antibodies and higher valency formats.Experience with developability assessments and formulation studies of lead candidate molecules.Track record of scientific accomplishments as evidenced by publications/patents, including expertise in biochemistry or biophysics. High throughput automation experience.EEO Statement:At PharmaEssentia Innovation Research Center (PIRC), we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PIRC believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool. - PIRC does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PIRC employees. PIRC is not responsible for any fees related to unsolicited resumes from staffing agencies. - -Powered by JazzHR

Keywords: PharmaEssentia U.S.A., Boston , Senior Scientist, Biochemistry, Biophysics, Protein Sciences, Other , Burlington, Massachusetts

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