Research Associate Scientist

Company: Takeda
Location: Boston
Posted on: November 20, 2023

Job Description:

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Job Description

About the role:

The Cell Engager team of Takeda's Oncology Drug Discovery Unit is looking for an in vivo/ ex vivo lab-based scientist to join a collaborative and dynamic team. Contribute to pre-clinical research projects by developing well-defined mechanistic experiments in immunology and oncology. The candidate should have a foundation in immunology and/or cancer biology with proven skills in in vivo models of cancer, and in vitro/ex vivo assays in immunology or oncology. The candidate will play a critical role in supporting key pipeline programs tied to Gamma Delta T cell biology and immune regulation mechanisms. The individual will collaborate and demonstrate effective communication and documentation of results with key stakeholders within a dynamic cross-functional R&D team. The selected candidate will be expected to conduct both in vivo and ex vivo lab assignments and protocols, d demonstrating initiative and innovative thought when designing experiments for drug discovery research. The position will require the individual to be primarily lab based.

How you will contribute:

ACCOUNTABILITIES

• Design and complete in vivo and ex vivo experiments with a primary focus on efficacy, pharmacokinetics and MOA studies in a range of in vivo (syngeneic, xenograft) and ex vivo/in vitro model systems with minimal supervision.
• Perform standard and complex in vivo procedures, such as dosing all routes, tumor inoculation, tumor measurements and tissue necropsy with minimal guidance.
• Data analysis, interpretation, and presenting findings to key stakeholders. Will play an active role in the subsequent scientific discussions to guide decision making and aid success of research programs.
• Initiate investigation of new experimental approaches to specific problems using scientific theory, data from external partners, and technical literature.
• Perform isolation of primary immune cells like PBMCs, alpha beta and gamma delta cells from peripheral blood and skin as required.
• Assist with external collaborations with CROs and establish new protocols.
• Ability to multi-task effectively and prioritize workload.
• Ability to work in a matrixed environment across teams.
• Prepares and presents comprehensive technical or project reports and formal presentations.
• Maintain excellent documentation through timely data analysis and ELN entries.
• Contributes to IND report and documentation.
  
  DIMENSIONS AND ASPECTS
  
  • Demonstrates in-depth technical in vivo knowledge.
  • Able to clarify requests, provide suggestions and put study design and quality of data into context.
  • Serves as the preclinical in vivo representative or lead on project teams, to provide scientific input or guidance into a matrix style team.
  • Assist with external collaborations with CROs.
  • Present and analyze data that can be decisional.
  • Conducts scientific presentations to internal audiences.
  • Collaborates with others across sites and acts as scientific resource for in vivo models of cancer.
  • Strives towards expanding scientific knowledge in immunology and animal models of cancer.
  • Receives high level instructions on routine work; general instructions on new assignments; able to execute on assigned tasks with some supervision.
    
    Minimum Requirements/Qualifications:
    
    • MS in a scientific discipline (or equivalent) with 3+ years relevant experience, or BS with 5+ years relevant experience.
    • Proficiency in in vivo rodent models of cancer, experience in mouse syngeneic and xenograft models required. Experience with humanized mouse models and PDX models preferred.
    • Strong experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection and ex-vivo processing.
    • Experience in cell culture with tumor cell lines, primary cells, and immune cells is required.
    • Experience of cell-based techniques such as flow cytometry or live cell imaging preferred.
    • Experience with cell-based functional ex vivo/in vitro assays is a must.
    • Strong interpersonal, time management and organizational skills.
    • Self-motivated and innovative.
    • Rigorously evaluating and analysing scientific data and forming conclusions.
    • Excellent oral and written communication skills.
    • Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc.)
    • Excellent team player with a collegial, can-do attitude who can thrive in a dynamic "biotech- like" environment to work in cross-functional matrix-style teams.
      
      What Takeda can offer you:
      
      • Comprehensive Healthcare: Medical, Dental, and Vision
      • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach Programs and company match of charitable contributions
      • Family Planning Support
      • Flexible Work Paths
      • Tuition reimbursement
        
        More about us:
        
        At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
        
        Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
        
        Base Salary Range: $91,700.00 to $131,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.
        
        The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.
        
        Empowering Our People to Shine
        
        Discover more at takedajobs.com
        
        No Phone Calls or Recruiters Please.
        
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        EEO Statement
        
        Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
        
        Locations
        
        Boston, MA
        
        Worker Type
        
        Employee
        
        Worker Sub-Type
        
        Regular
        
        Time Type
        
        Full time

Keywords: Takeda, Boston , Research Associate Scientist, Other , Boston, Massachusetts