Research Sr. Scientist, Gamma Delta T-Cell Engagers
Posted on: November 20, 2023
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About the role:
The Cell Engager team of the Oncology Drug Discovery Unit is
seeking an experienced and highly motivated immunologist, with a
strong background in immune-oncology and innate cell immunology.
The successful candidate will play an important role in optimizing
VD1 cell engagers, to improve the biological function (potency and
persistence) of gamma delta cell engager products (i.e., immune
cell activation, survival, proliferation, and function, and
cancer/immune biology in tumor microenvironment). The scientist
will lead discovery projects and collaborate with colleagues both
within the department, and with cross-function teams to drive the
development of Cell Therapy discovery platforms. The position is a
lab-based role, requiring strong leadership from the bench and a
hand-on attitude. The candidate should be able to independently
design, develop and execute research assignments, contributing to
multiple projects in early staged matrix project team.
How you will contribute:
- Contribute to discovery projects by independently designing and
developing well-defined mechanistic experiments and projects within
oncology cell engager research.
- Lead from the lab to advance novel and differentiated Cell
engager and cell therapy combination in collaboration with cell
therapy groups within the oncology department products toward
clinical milestones, by working collaboratively with internal
cross-functional teams and external partners.
- Design, execute, and interpret functional in vivo, in vitro,
and ex vivo assays to understand the mechanism-of-action and play
an active role in subsequent scientific discussions to drive
- Propose novel project ideas based on internal results, external
partners, and published reports and demonstrate leadership through
effective communication of study plans/value, and research
- Identify and integrate technologies that improve or expand the
ability to assess the MoA of novel immunomodulatory agents.
- Actively participate with team to help isolate VD1 cells from
blood and skin.
- Collaborate with CTI to incorporate new VD1 isolation
strategies for use in cell engager programs in vitro and in
- Contributes to the design and evaluation of novel engagers in
in vitro and ex vivo model systems.
- Contribute to the writing of relevant research reports to be
included in regulatory filings.
- Prepares and presents comprehensive technical or project
reports and formal presentations / posters to full range of
- Maintain laboratory notebooks and keep in compliance with
DIMENSIONS AND ASPECTS
- Demonstrates theoretical knowledge of cell engager
- Keeps current with emerging trends in immune cell engagers for
application in cancer therapy.
- Able to clarify requests and provide suggestions and put data
into context, with a key focus on assay design and quality of
- Demonstrates in-depth technical knowledge within various assay
- Demonstrates program management skills.
- Independently investigates new immunological techniques, that
can be applied to team projects.
- Serves as the in vivo immunobiology lead on projects providing
key scientific feedback to advance programs in a matrixed
- Independently manages workload and comfortable with key
- Scientifically independent
- Provides information to group to influence direction,
departmental goals and/or business.
- Conducts scientific presentations to internal audiences.
- Collaborates with others across sites and acts as scientific
resource for in vitro pharmacology.
- Participates in and supervises external interactions and
collaborations with external companies, academic research groups
- Expected to participate in new target identification /
- Strives towards expanding scientific knowledge in
- Receives high level instructions on work; determines methods on
new assignments; demonstrated greater independence; may manage
interns or junior staff.
- PhD degree in a scientific discipline with 3+ years'
experience, or MS with 9+ years' experience, or BS with 11+ years'
- Strong understanding Innate immunology or Gamma Delta biology
- Profound skills in in vitro and in vivo immune cell
characterization and function assessment, such as, multi-color flow
immunophenotyping, multiplex cytokine measurement, cytotoxicity
assay, and other molecular based assays and cell-based
- Strong understanding of in vivo preclinical model systems
applicable in caner immunotherapy
- Proficient in the isolation, culture, and functional
characterization of primary human immune cells.
- Proficient with ex vivo models for screening IO therapies is
- Experience with biologics is a must (Antibodies, ADCs,
bispecific and Cell therapies etc.)
- Experience leading projects sub teams and working with cross
functional matrixed teams.
- A demonstrated track record of independent critical thinking
and scientific achievement
- Excellent team player with a can-do attitude with an ability to
thrive in a dynamic "biotech- like" environment and work in
cross-functional project teams.
- Self-motivated, collaborative with excellent time management
and organizational skills
What Takeda can offer you:
- Comprehensive Healthcare: Medical, Dental, and Vision
- Financial Planning & Stability: 401(k) with company match and
Annual Retirement Contribution Plan
- Health & Wellness programs including onsite flu shots and
- Generous time off for vacation and the option to purchase
additional vacation days
- Community Outreach Programs and company match of charitable
- Family Planning Support
- Flexible Work Paths
- Tuition reimbursement
More about us:
At Takeda, we are transforming patient care through the development
of novel specialty pharmaceuticals and best in class patient
support programs. Takeda is a patient-focused company that will
inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating
careers, encourages innovation, and strives for excellence in
everything we do. We foster an inclusive, collaborative workplace,
in which our teams are united by an unwavering commitment to
deliver Better Health and a Brighter Future to people around the
Base Salary Range: $130,200.00 to $186,000.00, based on candidate
professional experience level. Employees may also be eligible for
Short-term and Long-Term Incentive benefits as well. Employees are
eligible to participate in Medical, Dental, Vision, Life Insurance,
401(k), Charitable Contribution Match, Holidays, Personal Days &
Vacation, Tuition Reimbursement Program and Paid Volunteer Time
The final salary offered for this position may take into account a
number of factors including, but not limited to, location, skills,
education, and experience.
Empowering Our People to Shine
Discover more at takedajobs.com
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Takeda is proud in its commitment to creating a diverse workforce
and providing equal employment opportunities to all employees and
applicants for employment without regard to race, color, religion,
sex, sexual orientation, gender identity, gender expression,
parental status, national origin, age, disability, citizenship
status, genetic information or characteristics, marital status,
status as a Vietnam era veteran, special disabled veteran, or other
protected veteran in accordance with applicable federal, state and
local laws, and any other characteristic protected by law.
Keywords: Takeda, Boston , Research Sr. Scientist, Gamma Delta T-Cell Engagers, Other , Boston, Massachusetts
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