Research Senior Scientist, Antibody Discovery & Engineering, In Vivo Based Methods
Company: Takeda Pharmaceutical
Location: Boston
Posted on: September 30, 2024
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAbout the role:At Takeda, we are a
forward-looking, world-class R&D organization that unlocks
innovation and delivers transformative therapies to patients. By
focusing R&D efforts on four therapeutic areas and other
targeted investments, we push the boundaries of what is possible in
order to bring life-changing therapies to patients worldwide.Join
Takeda as a Senior Scientist where you will use state-of-the-art
discovery technology and creating novel treatments to make a large
impact on patients' lives in the fields of Oncology,
Gastroenterology and Neuroscience. As part of the team,
contribution to swift and efficient discovery of biologic
therapeutics using in vivo based approaches is the core remit. You
will include deep scientific engagement and involvement in
programs; defining the best path forward based on the therapeutic
needs, designing immunization strategies, performing
immunizations/animal handling and tissue harvest, and conducting HT
antibody discovery using technologies using single B cell cloning
coupled with NGS. You will also necessitate familiarity with
associated screening workflows and data analysis in addition to
possessing a sound knowledge of B cell biology, humoral immunity
and immunoglobulin genetics and familiarity with basic building
block biologics IgG, Fab, sdAb, as well as design and optimize lead
candidates using display-based technologies (yeast, phage) may also
be part of the role. As part of the Biotherapeutic Engineering
team, you will report to the Senior Director of the organization
and interface very closely with cross functional project team
members to make data driven decisions with impact on pipeline is
vital. Here, you will recognize, and streamline for the most
efficient ways of working is a high priority in this role, which
requires tremendous drive, motivation to deliver (and beat) team
and program goals, while also pushing the boundaries to enhance
discovery and optimization. Working and networking excellently
within the team is critical for best performance and team
engagement as you will be part of a team of motivated and
enthusiastic scientists in the Cambridge, MA location, bringing
strong experience in antibody/biologic discovery to the team.How
you will contribute:
- Draw on expertise from antibody discovery to provide and lead
thoughtful guidance on strategies towards candidate profiles for
differing target types, including discovery and optimization/
engineering approaches to enhance properties.
- Strategize, optimize, and perform B cell separation and refined
enrichment techniques for antigen-specific antibody screening that
will include plasma and memory B cell sorting (Beacon and FACS
based methods). Continually improve single-cell RT-PCR, PCR,
molecular cloning, and BCR sequence analysis to best harvest
variable antibody regions for expression, NGS and/or repertoire
cloning into display platforms, with associated analysis and
management of data. Collaborate effectively with high-throughput
mammalian expression teams for downstream work, while working with
teams to best define overall triage funnels and steps.
- Work closely with NGS discovery team to best strategize and
thoughtfully apply NGS based analysis throughout the discovery
process and lead for change in establishment of the best feedback
loop of discovery/optimization for therapeutics.
- Construct immune based repertoires from animal sources for
manipulation in display-based platforms from discovery through
optimization.
- Have involvement in design of maturation libraries for display
platforms (affinity/ potency/ stability) leveraging datasets,
experience, and software to improve lead candidates.
- Manage sequence analysis through state-of-the-art tools for
deep understanding and performance of campaigns.
- Work with data analysis tools to ensure thorough evaluation of
datasets and information based decision making, in addition to
summarize and present findings to smaller and larger teams.
- High level of diligence in all data tracking, uploading and
recording using data management systems within the department.
- Oversee and manage workflows with thirds parties and/or CROs
where appropriate.
- Serve as an effective point of contact for discovery programs,
collaborate and interact with team members and other internal
groups for high efficiency and transparency to enable progression
of molecules.
- Demonstrate pro-activity through identifying areas to improve
efficiency, perform technology development to bring new innovation
to the team, where appropriate.
- Independently design, develop and execute research assignments
and contribute to multiple projects, in parallel.
- Work efficiently with a sense of urgency to meet program and
team needs, setting high standards for effectivness of execution,
efficience and rigor of thought.Minimum
Requirements/Qualifications:
- PhD degree in a scientific discipline (or equivalent) with 2+
years relevant experience, or MS with 8+ years relevant experience,
or BS with 10+ years relevant experience.
- Excellent experience of in vivo immunization strategies and
handling antibody discovery platforms, specifically single B cell
cloning, with adeptness in FACS based sorting strategies.
- Excellent knowledge of antibody discovery and engineering, B
cell biology, humoral immunity and immunoglobulin genetics.
- Good familiarity with antibody repertoire analysis- NGS data
handling and analysis from either in vivo or in vitro sources.More
about us:At Takeda, we are transforming patient care through the
development of novel specialty pharmaceuticals and best in class
patient support programs. Takeda is a patient-focused company that
will inspire and empower you to grow through life-changing
work.Certified as a Global Top Employer, Takeda offers stimulating
careers, encourages innovation, and strives for excellence in
everything we do. We foster an inclusive, collaborative workplace,
in which our teams are united by an unwavering commitment to
deliver Better Health and a Brighter Future to people around the
world.#LI-SGM#LI-OnsiteTakeda Compensation and Benefits SummaryWe
understand compensation is an important factor as you consider the
next step in your career. We are committed to equitable pay for all
employees, and we strive to be more transparent with our pay
practices. -For Location:Boston, MAU.S. Base Salary
Range:$133,000.00 - $209,000.00The estimated salary range reflects
an anticipated range for this position. The actual base salary
offered may depend on a variety of factors, including the
qualifications of the individual applicant for the position, years
of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.---The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. -U.S. based employees may be
eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Boston , Research Senior Scientist, Antibody Discovery & Engineering, In Vivo Based Methods, Other , Boston, Massachusetts
Didn't find what you're looking for? Search again!
Loading more jobs...