Head of Global Chemistry

Company: Takeda Pharmaceutical
Location: Boston
Posted on: September 30, 2024

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionThe Head of Global Chemistry acts as the strategic leader of the global drug discovery chemistry team and a core member of the Research leadership team that designs and creates innovative assets across the organization's key therapeutic areas. They will manage an international team that is responsible for overseeing all aspects of medicinal chemistry, related to hit identification through to IND filing for small molecule and oligonucleotide therapeutics as well as the preclinical development of target occupancy and disease progression PET ligands. The Head of Global Chemistry employs enterprise thinking, multi-disciplinary scientific rigor, and business development creativity to leverage partnerships with specialist internal and external organizations to produce innovative small molecule and oligonucleotide therapeutics that possess the potential to become life improving medicines for diseases that align to the company's Therapeutic Area Strategy.Position Description:

• Contribute to the Research leadership team, beyond specialist input on medicinal chemistry, to ensure that research productivity meets therapeutic area unit clinical development needs and the company's commercial goals;
• Drive the strategic evolution, direction, and leadership of chemistry teams responsible for asset and PET ligand generation for multiple drug discovery programs targeting oncology, neuroscience and gastrointestinal/inflammatory diseases, from hit identification to IND filing;
• Dynamically manage the resourcing and prioritization of each chemistry program based on scientific and therapeutic area priority considerations to deliver clinical development compounds within their agreed timelines;
• Continuously evaluate and elevate the productivity and capabilities of the global chemistry team through adoption of cutting-edge technologies and the latest scientific approaches by, for example, building partnerships with key external experts, including academic institutions, research organizations, and industry partners, to harness the best science, including implementation of state-of-the-art AI/ML tools/processes, wherever and whenever they emerge in the world;
• Be seen as an inspirational international subject matter expert and global thought leader in medicinal chemistry that fosters a culture of innovation and scientific excellence within the global chemistry team, promoting visionary thinking, knowledge sharing, and continuous learning;
  • Build effective working relationships with internal business partners to enable program teams to work effectively with cross-functional teams, including internal biology, pharmacokinetic, toxicological, and pharmaceutical sciences teams as well as external partners, to develop and execute chemistry programs/strategies within each drug discovery program in the Research portfolio;
  • Share best practices with other groups within Research and deploy enterprise thinking to maximize the success of Research as a whole;
  • Provide guidance and mentorship to team members, fostering their professional growth and development, retaining top talent and ensuring that everyone can achieve their full potential by establishing an equitable and inclusive working environment that is rich in diversity;
  • Implement approved ways of working to ensure that the global chemistry team can work in a safe, legally compliant and fiscally accountable environment that provides its members with an industry leading work experience;
  • Act as a Company Research ambassador at external public events e.g., media events, scientific review committees.This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policyQualifications:
    • Advanced degree in organic/medicinal chemistry or related field (e.g., Ph.D.) with 15 years industry and 15 years management experience;
    • Specialist knowledge in cutting edge drug discovery methodologies including ligand and structure-based drug design, parallel synthesis and machine learning generative AI design to advance drug discovery projects to clinical development;
    • Strong leadership skills and demonstrated ability to manage productive/diverse international team(s);
    • Well informed deep understanding of the drug discovery process, including high-throughput screening, hit-to-lead optimization, and preclinical development;
    • Extensive experience in formulating and implementing chemistry strategies for asset and PET ligand generation preferably in a pharmaceutical or biotechnology setting;
    • Strong business acumen and understanding of the pharmaceutical industry, including drug development regulations/processes as well as commercial considerations;
    • Proven track record of disciplined decision making that lead to the successful execution of internal drug discovery programs to deliver clinical development candidates;
    • Ability to build effective relationships with key stakeholders to secure support and build successful internal working practices on a global stage to progress multiple oligonucleotide and small molecule assets from program start to IND;
    • Demonstrated success in building and managing external high impact strategic partnerships with academic institutions, research organizations, and industry collaborators that have progressed to clinical development;
    • Excellent leadership, decision making and strategic planning skills with the ability to inspire and motivate teams towards achieving ambitious goals;
    • Good external publication record, exceptional communication, and presentation skills, with the ability to communicate complex scientific concepts effectively to diverse audiences internally and externally.Takeda Compensation and Benefits SummaryWe understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. -For Location:Boston, MAU.S. Base Salary Range:$330,400.00 - $454,300.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.---The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. -U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. -EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAJPN - Kanagawa - FujisawaWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

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