Senior Scientist, Systems Biology
Company: Takeda Pharmaceutical
Location: Boston
Posted on: September 30, 2024
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAt Takeda, we are a forward-looking,
world-class R&D organization that unlocks innovation and
delivers transformative therapies to patients. By focusing R&D
efforts on three therapeutic areas and other targeted investments,
we push the boundaries of what is possible in order to bring
life-changing therapies to patients worldwide.Certified as a Global
Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world.Are you looking for a
patient-focused, innovation-driven company that will inspire you
and empower you to shine? Join us as a Senior Scientist, Systems
Biology in our Cambridge, MA location.Objective / Purpose:
- Be part of a computational team focused on utilizing in silico
and systems biology approaches to support Takeda drug discovery and
development projects.
- Utilize advanced bioinformatics, computational, AI/ML, and
graph learning techniques to analyze multi-omic and multi-modal
data, and identify novel drug targets, biomarkers, and cellular
mechanisms of action across the Gastroenterology and Inflammation
portfolio. -
- Evaluate the efficacy of potential target candidates through
the application of state-of-the-art computational approaches;
working closely with experimental, biology, computational genetics,
data science, quantitative statistics, engineering, translational
medicine, and biomarker teams.
- Report to the Computational Biology Group leader and
collaborate with key stakeholders to drive innovative therapies for
inflammatory bowel disease, chronic liver disorders, and chronic
inflammatory indications in dermatology and
rheumatology.Accountabilities:
- Serve as a subject matter---expert in projects requiring
multi-omic and multi-modal analyses from preclinical and clinical
studies to identify and execute biomarker studies, patient
stratification, and identify novel drug -targets/biomarkers. -
- Use multimodal/foundational models including but not limited to
clinical data, single-cell, and genomics.
- Develop AI/ML models, knowledge graphs and NLP pipelines;
incorporate computational strategies with graph-neural networks,
deep learning, multimodal fusion, transformer models, transfer
learning, contrastive learning as appropriate.
- Present scientific reports in internal meetings in all settings
and with participants of all levels of the organization, as well as
for external audiences. -
- Proactively identify complex obstacles, recommend and implement
solutions using a diverse set of resources. -
- Work collaboratively with data and quantitative scientists and
data engineering groups to enhance our computational
infrastructure, build on innovative C&SB solutions and
intuitive multi-omics interface. -Technical/Functional (Line)
Expertise
- Strong knowledge of molecular biology and genomics.
- Biological knowledge in one or more areas of inflammation and
fibrosis (IBD, chronic liver disorders, chronic inflammatory
indications in dermatology and rheumatology)
- Demonstrated experience in large scale multi-omics (e.g. bulk
or single-cell, spatial sequencing, proteomics, epigenetics, and
more), multi-modal data integration, network analysis, and
meta-analyses.
- Strong machine learning experience is preferred.
- Statistical analysis experience with working knowledge of
regression analysis, multivariate data analysis, and
linear/nonlinear mixed effects modeling is preferred.
- Demonstrated ability to integrate and analyze multimodal
biomedical data.
- Background and work experience in graph-neural networks, deep
learning, multimodal fusion, transformer models, transfer learning,
contrastive learning.
- Experience in developing clinical knowledge graphs and working
with NLP and retrieval-augmented generation pipelines.
- Experience with multimodal/foundational model development
including but not limited to clinical data, single-cell, and
genomics.
- Ability to independently solve scientific problems using
multiple, state-of-the-art technologies and approaches.
- Experience with computational method evaluation, development,
and implementation.
- Solid knowledge of Unix/Linux, command line interfaces, and
fluency in some common scripting and/or programming language (e.g.,
R, Python, Perl, Java, C / C++) used for statistical and
computational multi-omics analysis.
- Experience with high performance computing, relational
databases (e.g., SQL), and cloud computing or distributed computing
(Amazon Web Services).Innovation
- Receives high level instructions on all work, determines
methods for new assignments, works closely with manager, may manage
junior staff Determines methods for new assignments; perform
literature search as needed to propose and develops innovative
solutionsInteraction
- Conducts scientific presentations to internal
audiencesDecision-making and Autonomy
- Independently manages own workload Scientifically independent
Ability to search literature and come up with innovative solution
to difficult problemsLeadership
- Ability to work in a team and influence team to make data
driven decisionsEducation & Competencies
- PhD degree in Systems Biology, Bioinformatics or Computational
Biology with 2+ years relevant experience, or MS with 8+ years
relevant experience, or BS with 10+ years relevant experience.
- Previous industry experience is preferred and a strong
background in applying computational and systems biology, including
multi-omics data analyses, to research, translational and clinical
programs with demonstrated ability to meet program objectives and
timelines.
- Strong organizational and effective communication skills.This
position is currently classified as "hybrid" by Takeda's Hybrid and
Remote Work policyTakeda Compensation and Benefits SummaryWe
understand compensation is an important factor as you consider the
next step in your career. We are committed to equitable pay for all
employees, and we strive to be more transparent with our pay
practices. -For Location:Boston, MAU.S. Base Salary
Range:$133,000.00 - $209,000.00The estimated salary range reflects
an anticipated range for this position. The actual base salary
offered may depend on a variety of factors, including the
qualifications of the individual applicant for the position, years
of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.---The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. -U.S. based employees may be
eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Boston , Senior Scientist, Systems Biology, Other , Boston, Massachusetts
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