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Associate Scientist II / Scientist I, Tau

Company: AbbVie
Location: Cambridge
Posted on: May 18, 2018

Job Description:

AbbVie has established the AbbVie Cambridge
Research Center in Cambridge, MA to investigate the fundamental biological
mechanisms and to develop therapeutic interventions for neurodegenerative
disorders such as Alzheimer's and Parkinson's diseases. The Tau Biology group
is seeking a highly motivated applicant with prior experience and expertise in
target validation and assay development in neuroscience. This Scientist will support a project
leader in 1) investigate mechanisms regulating neuron-to-neuron spread and the resulting
accumulation of misfolded protein in AD using transgenic animal models and
human postmortem tissues, 2) conduct microscopic image-based studies to screen
for antibodies and small molecules in neurons.
Key Responsibilities
Include:Analyze human AD brain tissues and extract protein of interest
using western blot, MSD, and other biochemical assaysCulture hiPSC (human-induced pluripotent stem cell) neurons and
rodent primary neuronsDesign and perform tau aggregation inhibition studies in
neuronal cultures using confocal microscopy, high-content imaging,
high-throughput robotic-assisted imaging.
Analyze and present the results to validate novel drug targets.Work diligently and efficiently to meet deadlines in a
fast-paced environment.Read and apply relevant scientific literature.

























Position will be hired based on level of experience. Basic Qualifications: BS or MS degree in System Neuroscience or related field with 3-5+ (BS) or 0-2+ (MS) years of pharmaceutical industry experience. Proficiency with standard cell biology, biochemistry, and microscopy methodsExpertise in developing biochemical and cellular assays for high throughput screening.Familiarity with plate readers and/or high content imaging / familiarity with neuroanatomy is plus but not required.Comfortable using computer programs such as Microsoft, Google Docs, Microsoft Excel, etc.Highly motivated, detailed oriented, curious of the science, and desire to learn to novel neuroscience techniques.Demonstrate critical thinking, independence, clear scientific writing & verbal communication skills and precise record keepingStrong organizational skills that facilitate planning, multitasking and working within timelines.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled

Keywords: AbbVie, Boston, Associate Scientist II / Scientist I, Tau, Other, Cambridge, Massachusetts

Click here to apply!

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