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Principal Scientist, Cancer Biology

Company: Nuvalent
Location: Cambridge
Posted on: February 15, 2019

Job Description:



Responsibilities

  • Be a highly collaborative member of an emerging cross-functional team advancing high quality drug candidates.
  • Work as a part of a team, but also take a leadership role to identify, design and direct outsourced PK/PD, tolerability, efficacy and biomarker studies of lead compounds in rodent models.
  • Coordinate biological evaluation of lead compounds.
  • Participate in the identification and nomination of new targets. Qualifications
  • Ph.D. in cancer biology or related field with 7+ years of experience in the (bio)pharmaceutical industry
  • Deep knowledge and demonstrated analytical and problem-solving skills in Cancer Biology
  • Broad experience in developing and working with in vivo cancer models for the evaluation of small molecules, especially PDX models
  • Expertise in molecular biology, tissue culture and cell biology assays, including real-time PCR, DNA cloning, Western blot, immunoprecipitation, ELISA, Next Generation Sequencing, viral transductions, flow cytometry, and microscopy
  • Deep understanding and knowledge of the kinase inhibitor space
  • Excellent understanding of the drug discovery process and a proven track record of contributing to the identification of lead compounds and clinical candidates
  • Strong oral and written communication skills
  • Excellent team player
  • Experience coordinating outsourced biological studiesEmployer provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. PM18 4

    Keywords: Nuvalent, Boston , Principal Scientist, Cancer Biology, Other , Cambridge, Massachusetts

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