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Associate - Bioassay & Profiling

Company: Amgen
Location: Cambridge
Posted on: August 18, 2019

Job Description:

The Therapeutic Discovery organization is seeking a highly motivated and capable Associate to join the Bioassay & Profiling group within the Discovery Technologies department in Cambridge, MA (Amgen Massachusetts-AMA). The successful candidate will be a bench scientist that contributes hands-on to our compound screening efforts in support of Amgen's small molecule drug discovery pipeline in collaboration with multiple therapeutic areas. The position focuses on the implementation and execution of established in vitro biochemical and cell-based assays to support HTS and lead optimization studies for promising therapeutic targets.Position Responsibilities include:Implement and scale assays from medium to high throughput (in 384 and/or 1536 well plates) screening applicationsPerform small molecule screening workflow, data analysis and data reportingWork with liquid handling instrumentation (e.g., Echo, Bravo, Tempest, or similar) and detection instrumentation (e.g., Envision, FLIPR, MSD, or similar)Learn, apply and incorporate automation workflows (scheduling software, protocol design, or other programming knowledge) and operating integrated robotics towards productive execution of routine screening assaysMaintain fluency with the latest lab automation and screening assay technologies, scientific literature surrounding drug targetsBe an active contributor to the interpretation of results in group discussionsExhibit excellent teamwork and collaboration as this role requires an ability to work closely with other scientists in the group and across AmgenAdhere to good laboratory conduct, documentation practices and safety guidelinesBasic QualificationsBachelor's degree ORAssociate's degree and 4 years of scientific experienceORHigh school diploma / GED and 6 years of scientific experiencePreferred QualificationsA Bachelor's Degree in Biology, Biochemistry, Bioengineering1+ years of research experience in a drug discovery laboratory setting working as part of a multi-disciplinary teamPrior experience executing biochemical and/or cell-based binding- and/or activity-based assays in 384 and/or 1536 plate formatExperience with operating, implementing and troubleshooting laboratory automationCell culture expertise (immortalized and/or primary cells)Successfully demonstrated initiative, teamwork, collaboration, an ability to multi-task and a passion for delivering results from routine assay execution and screeningAbility to create and establish priorities, manage work plans and adhere to timelinesCapacity to identify, evaluate, implement and become proficient in novel laboratory techniquesA flexible mindset, with strong interpersonal, communication and problem-solving skillsExperience in setting-up and operation of fluorescence/luminescence plate readers (e.g., FLIPR, Envision) and automated liquid handlers (e.g., Bravo, Echo, Tempest) across executing routine 384- and/or 1536-well microtiter plate screening assaysA scientific foundation in the understanding and implementation of a wide range of biochemical and cell-based screening assays and readouts (e.g., TR-FRET, BRET, PCA, AlphaScreen, fluorescence polarization, high content imaging, luminescence and fluorescence-based reporter and/or label-free assays) supporting drug discovery on novel therapeutic targetsFamiliarity with automation or integration workflow software programming and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire, Pipeline Pilot)Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.Join UsIf you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Keywords: Amgen, Boston , Associate - Bioassay & Profiling, Other , Cambridge, Massachusetts

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