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Cellular Process Development, Scientist I

Company: Bluebird Bio Inc.
Location: Cambridge
Posted on: November 12, 2019

Job Description:

Cellular Process Development, Scientist I

In search of an innovative scientist to enable the transition of Cellular Processes from Research to Development to Manufacturing

Join bluebird bio s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach. The focus of this position is to provide laboratory support a pre-clinical Cell Process Development team within Cellular Process Development and Gene Editing group. The team s activities include the development of cell manufacturing processes, process scale up and optimization, IND-enabling activities, and the tech transfer to a clinical manufacturing site, amongst others. The candidate will work closely with research and manufacturing cross-functional partners to ensure smooth transition of gene therapy cell processes from a research setting into GMP manufacturing. We seek candidates with cellular process development experience.

About the role:

* Responsible for the design, execution and interpretation of experimental studies in the laboratory

* Develop and perform experiments involving the isolation, transduction, expansion and cryopreservation of gene modified cells for the treatment for hematological malignancies and other cancers

* Develop, optimize and scale up a robust cell manufacturing process to support IND enabling studies and GMP manufacturing

* Mentor and guide junior scientists in the design and execution of their work

* Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation

* Collaborate closely with research to transition new cell processes from research to development

* Collaborate closely with manufacturing to tech transfer the developed process to a GMP facility and coordinating equipment procurement and training runs

* Participate in meetings as a subject matter expert in support of a preclinical program advancement to the clinic, as needed

* Author and review of technical documentation to support early stage activities (process development reports, tech transfer plans and reports and IND/regulatory submissions)

* Must be willing to have flexible schedule based on experimental and company needs (including possible weekend work and travel)



About you:

* BS with 6+ years, MS with 4+ years or PhD with relevant experience. Degree emphasis in cell biology, immunology, biological sciences, biomedical/chemical engineering or related field is preferred.

* Experience in mammalian cell culture process development with understanding of bioprocess engineering concepts

* Well versed in a variety of cell-based methods with a strong understanding of tissue culture, cell biology, immunoassays, and aseptic techniques

* Hands on experience in bioreactor and cell separation system operations

* Use of scientific methodology to solve problems or to pursue scientific inquiry

* Develop experimental plans, interpret scientific results, provide statistical analysis where appropriate, summarize and present scientific data and report progress on behalf of the team

* Willingness to work with lentiviral vector and human biological samples

* Experience in CAR-T or HSC cell culture technologies (CliniMACS, Prodigy, Sepax, Lovo, etc.) and/or process analytical technologies is a plus

* Previous experience training scientists in a laboratory setting is desired

* Strong communication, technical writing and presentation skills

* Ability to work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view

* Independently motivated, detail oriented and good problem-solving ability.

* Excellent organizational skills and ability to multi-task in an extremely fast-paced environment with changing priorities.

* Willingness to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself.

b yourself.
bluebird bio is committed to fostering an environment where everyone can be their whole selves and know they are valued. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. As an equal opportunity employer, we do not discriminate on the basis of race, religion, color, national origin, age, gender (including pregnancy, childbirth, or related medical conditions), sex, sexual orientation, gender identity, gender expression, age, disability, veteran status, or other applicable legally protected characteristics.

Keywords: Bluebird Bio Inc., Boston , Cellular Process Development, Scientist I, Other , Cambridge, Massachusetts

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