SVP, Head of Portfolio Strategy and Operations
Company: Dyne Therapeutics
Location: Waltham
Posted on: July 8, 2025
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Job Description:
Company Overview: Dyne Therapeutics is focused on delivering
functional improvement for people living with genetically driven
neuromuscular diseases. We are developing therapeutics that target
muscle and the central nervous system (CNS) to address the root
cause of disease. The company is advancing clinical programs for
myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy
(DMD), and preclinical programs for facioscapulohumeral muscular
dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to
deliver functional improvement for individuals, families and
communities. Learn more https://www.dyne-tx.com/ , and follow us on
X , LinkedIn and Facebook . Role Overview: The Head of Portfolio
Strategy and Operations (PS&O) drives successful delivery of
key corporate objectives by ensuring the robust development of
portfolio and program strategy and effective translation of
strategy into integrated planning and timely operational execution
across Dyne. The Head of PS&O reports into the Chief Executive
Officer (CEO) and is a member of the Dyne Executive Committee (EC).
The Head of PS&O oversees Program Leadership, Program
Management and Clinical Operations at Dyne by managing, coaching
and guiding the Head of Clin Ops, Head of PM and the Program Team
Leaders to enable exceptional performance of cross-functional
Program Teams and clinical studies across the Dyne portfolio: Leads
high-performing team of Program Team Leaders, driving the
articulation of program strategy, vision, goals and priorities,
bringing both a 'future- orientation' toward the ultimate goal of
broad, global commercial access for patients in need, and a
"pragmatic-orientation" to chart the path, mitigate risks,
cultivate options, and lead the company through complex drug
development decisions Oversees high-performing team of Program
Managers, including direct management of the VP, Head of Program
Management; driving achievement of company and program goals and
the advancement of the company’s portfolio of programs ensuring
effective cross-functional contributions from all company functions
Oversees high-performing Clinical Operations team, including direct
management of the VP, Head of Clinical Operations, and overall
accountability for team based in US and EU; drives exceptional
planning, start-up, conduct and close-out of Dyne clinical studies
in line with corporate goals Articulates and drives the vision for
how to build and scale the PTL, PM and Clin Ops organizations,
capabilities, processes and infrastructure to support Dyne future
growth As a member of Dyne Executive Committee, the Head of
PS&O partners with Dyne executive leadership team to integrate
and harmonize Business Operations across the organization, driving
portfolio level cross-program and cross-functional integration,
coordination and operations across Dyne: Oversees Dyne governance,
partnering with executive leadership to ensure timely, high-quality
and cross-functional decision-making and information sharing to
enable advancement of Dyne portfolio and programs Partners on the
Dyne strategic planning process with CFO, ensuring development of
robust program and project long- and short-range plans in line with
corporate goals and resources Partners with CMO to build out
integrated Development Operations capabilities to enable growth of
late-stage development programs and the expansion of Dyne’s
clinical pipeline. Oversees development of non-program operations
to ensure harmonization and alignment of project management
discipline and methodology across organization Key Responsibilities
of the Role: Lead and develop team of Program Team Leaders and
Program Managers to effectively advance Dyne Programs and foster
seamless integration and communication across the company: Drive
understanding and inspire the big picture thinking of corporate,
portfolio and program strategy and cross-functional
interdependencies in order to lead execution across all Programs
Partner with Program Team Leaders to provide strategic and
operational leadership to programs to achieve Program and company
goal Ensure effective partnership with cross-functional
representatives to develop comprehensive product development,
commercialization and lifecycle management plans that optimize:
value, time, resources, risk, and alignment with business
objectives Oversee and enable high-performing cross-functional
Program Teams, focusing on both the "what", such as strategy,
priorities, output, and resources, and also the "how", such as
maintaining a fulfilling, collaborative, and sustainable team
environment Establish a robust and well-understood Program strategy
for bringing a life-changing medicine to patients in need
Effectively manage the Program Team model at Dyne: Develop and
maintain clear Program plans understood by all team members with
all key activities, deliverables, responsibilities, and timing
Enable clear strategic decision making (articulate and align on
timing and approach for key decisions; prepare effective analyses
and materials for decisions; ensure decisions are understood and
implemented), scenario planning and options analysis Ensure
“health” of PT and Sub-Teams by proactively managing members’
engagement, communications, expectations, issue resolution, etc.
Develop foundations for effective Portfolio Management (integrated
portfolio views; key milestones and decisions; portfolio scenarios
for effective optimization) Develop, maintain and make available
Portfolio views in synch with Program plans and Dyne financials
plans Drive Portfolio Review preparation and decisions Partner and
Support yearly financial planning and LRP work Lead and develop
Clinical Operations team to effectively advance Dyne portfolio of
clinical studies: Provide strategic operational guidance to ensure
that trials are properly defined, planned, and executed to a high
degree of quality across all clinical stage programs Develop and
implement a clinical vendor oversight process with documentation to
record transfer of regulatory responsibilities, evaluation of
performance, and escalation of issues Establish, implement, and
proactively manage clinical trial processes, strategic outsourcing,
and performance indicators Ensure high standards for compliance and
quality within the Clinical Operations team and across clinical
trial vendors with company SOPs, ICH-GCP guidelines that govern
regulations, and patient safety standards Regularly report clinical
trial status, identify challenges and program/resource gaps, and
devise and implements solutions Provide strategic input to
clinical-trial related risk analysis and mitigation strategies
Oversee the development and review of clinical program budgets, and
track and forecast spend for initiated studies Lead or oversee the
authorship of Clinical Operations SOPs and other function-specific
documentation; participate in cross-functional SOP development and
infrastructure initiatives Knowledge & Skills Experience in Phase
1-3 drug development is required; product launch/early
commercialization experience a strong plus Proven and respected
leader with: Advanced degree in Medical or Life Science, MD, PhD or
MBA or equivalent 15 years of experience in pharmaceutical industry
in leadership positions in drug development and proven track record
in driving Programs through IND, early clinical, pivotal stages and
approval And/or at least 12 years in pharmaceutical industry in
significant development and/or commercial leadership or general
management positions including working with development teams in
cross-functional setting, with exceptional track record of
delivering on business objectives, activity/milestones leading to
filing and launching, and strong knowledge of neuromuscular
diseases Experience in rare genetic diseases preferred Previous
Clinical Operations functional and/or program leadership, including
hiring and managing Clinical Operations staff, selecting and
managing vendors/CROs, and optimizing resources across clinical
studies Other Key Traits Include: Business-oriented leader, able to
shape and communicate the vision for the Dyne portfolio and
programs and guide the development of the product strategy and its
execution Natural focus on team dynamics; insightful people leader
supporting and coaching high-caliber functional experts to achieve
their absolute best Demonstrated experience in building highly
effective teams and guiding teams and organizations in making
complex and high-stakes data-driven decisions Outstanding sense of
urgency and ability to pace the team’s work to achieve milestone
achievement in highly competitive environment Excellent
communication skills (verbal, written, presentation) and ability to
communicate well with all stakeholders and teams Comfort with
ambiguity and ability to provide steadiness and consistency in
environment of shifting priorities, demands and timelines LI-Onsite
The statements contained herein reflect general details as
necessary to describe the principles functions for this job, the
level of knowledge and skill typically required, and the scope of
responsibility, but should not be considered an all-inclusive
listing of work requirements. Individuals may perform other duties
as assigned, including work in other functional areas to cover
absences or relief, to equalize peak work periods or otherwise
balance workload. This description is not intended to be
constructed as an exhaustive list of duties, responsibilities, or
requirements for the position. This position may change or assume
additional duties at any time. The employee may be requested to
perform different or additional duties as assigned. All Employees
are expected to adhere to all company policies and act as a role
model for company values. Dyne Therapeutics is an equal opportunity
employer and will not discriminate against any employee or
applicant on the basis of age, color, disability, gender, national
origin, race, religion, sexual orientation, veteran status, or any
classification protected by federal, state, or local law.
Keywords: Dyne Therapeutics, Boston , SVP, Head of Portfolio Strategy and Operations, Science, Research & Development , Waltham, Massachusetts
