Hands-on Principal Scientist, Biochemistry

Company: Envoya
Location: Natick
Posted on: February 20, 2026

Job Description:

JD – Hands-on Principal Scientist, Biochemistry Join us at ENVOYA, where innovation, dynamism, and cutting-edge discovery unite to create a brighter future for medicine and patients worldwide. ENVOYA is a gene therapy company focused on advancing next-generation gene therapy delivery, with a growing portfolio of proprietary delivery technologies and internal therapeutic assets. Be part of an exciting journey to transform drug delivery and improve patients’ lives. We are passionate about delivering life-changing solutions through groundbreaking research and technology and are seeking a dynamic, self-motivated, hands-on Principal Scientist in biochemistery to play an instrumental role in our research and development efforts. As a member of our exceptional team, you will be responsible for planning and executing scientific research, with a primary focus on hands-on laboratory experimentation to advance our gene therapy delivery platforms and internal programs. ENVOYA embraces a culture of scientific discovery. We are pushing the boundaries of what’s possible in gene therapy delivery and working to revolutionize the pharmaceutical landscape through innovative science and execution. Agility We are looking for individuals who are dynamic and agile, as our organization thrives in a fast-paced, startup environment. Our ability to adapt quickly to emerging trends, cutting-edge technologies, and scientific breakthroughs allows us to stay ahead of the curve. Collaborative Excellence We believe excellence is best achieved through collaboration. Our team is comprised of brilliant scientists, researchers, engineers, and industry experts who share a common goal of making a meaningful difference. Together, we leverage diverse expertise to tackle complex challenges, foster interdisciplinary approaches, and create solutions that transform gene therapy treatment. Impact on Patients Ultimately, our work is driven by a deep sense of responsibility to improve patients’ lives. We understand that each discovery has the potential to bring hope and relief to millions of people worldwide. This responsibility fuels our determination to translate promising ideas into practical gene therapies that address unmet medical needs and redefine healthcare. This is a unique opportunity to be part of a standout team building transformative gene therapy delivery technologies and therapeutic assets from the ground up. ABOUT ENVOYA ENVOYA is a leading pioneer in the field of advanced biomedical technologies, focusing on gene therapy. Our company is dedicated to revolutionizing the world of gene therapy through the development of polymer- based nanoparticles for targeted delivery. By harnessing the power of generative AI and nanotechnology, we aim to overcome the challenges associated with traditional gene therapies and unlock new possibilities for treating a wide range of genetic disorders and diseases. IN THIS ROLE YOU WILL Personally design and execute the formulation and characterization of polymer-based nanoparticles for targeted drug delivery. Maintain hands-on assay development, troubleshooting, and iteration for nanoparticle characterization and drug release studies. Analyze experimental data directly and use results to guide next experimental steps in formulation optimization. Rapidly iterate on designs and approaches based on real-time data from physiochemical, in vitro, and in vivo assays. Collaborate with cross-functional partners on projects integrating material science, in vivo studies, and therapeutic assets. Contribute to polymer chemistry and nanoparticle delivery platforms optimization, focusing on drug loading, stability, and controlled release. BASIC REQUIREMENTS Ph.D. in Biochemistry, Materials Science, Chemical Engineering, or a relevant scientific discipline. Industry experience with substantial hands-on work in nanoparticle formulation, drug delivery systems, and biological assays. Demonstrated ability to independently design, execute, and interpret complex experiments related to material characterization, in vitro efficacy, and in vivo targeting. Strong technical depth in polymer chemistry, materials science, and nanoparticle-based drug delivery. Comfort working at the bench in a fast-paced, resource-lean startup environment. Ability and desire to work collaboratively on complex problems integrating data from multiple disciplines. Understanding the biological challenges in drug delivery and ability to translate this understanding into technical solutions that ensure successful targeted delivery and maximize therapeutic efficacy. A PERFECT CANDIDATE HAS Passion and self-motivation with an exceptional internal drive to get things done in a fast-paced environment. Excitement about the vision and mission of Envoya to redefine gene therapy delivery by challenging the “normal” process. Deep expertise in nanoparticle characterization, stability studies, and controlled drug release mechanisms. Experience with advanced polymer synthesis and function for enhanced targeting and biocompatibility. Prior experience in early-stage biotech or highly execution-focused teams. Experience with in vivo efficacy and biodistribution studies of nanoparticle formulations, understanding the biological challenges.

Keywords: Envoya, Boston , Hands-on Principal Scientist, Biochemistry, Science, Research & Development , Natick, Massachusetts